ID   H0WWU8_OTOGA            Unreviewed;       864 AA.
AC   H0WWU8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=dipeptidyl-peptidase IV {ECO:0000256|ARBA:ARBA00012062};
DE            EC=3.4.14.5 {ECO:0000256|ARBA:ARBA00012062};
GN   Name=DPP9 {ECO:0000313|Ensembl:ENSOGAP00000006881.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006881.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000006881.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a
CC         polypeptide, preferentially when Yaa is Pro, provided Zaa is neither
CC         Pro nor hydroxyproline.; EC=3.4.14.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001257};
CC   -!- SIMILARITY: Belongs to the peptidase S9B family. DPPIV subfamily.
CC       {ECO:0000256|ARBA:ARBA00010036}.
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DR   EMBL; AAQR03058982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03058983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0WWU8; -.
DR   STRING; 30611.ENSOGAP00000006881; -.
DR   Ensembl; ENSOGAT00000007695.2; ENSOGAP00000006881.2; ENSOGAG00000007691.2.
DR   eggNOG; KOG2281; Eukaryota.
DR   GeneTree; ENSGT00940000158174; -.
DR   HOGENOM; CLU_006105_1_0_1; -.
DR   InParanoid; H0WWU8; -.
DR   OMA; VTHMTPQ; -.
DR   TreeFam; TF313309; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0031252; C:cell leading edge; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005874; C:microtubule; IEA:Ensembl.
DR   GO; GO:0008239; F:dipeptidyl-peptidase activity; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0043069; P:negative regulation of programmed cell death; IEA:Ensembl.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   GO; GO:0070269; P:pyroptosis; IEA:Ensembl.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR045785; Dpp_8/9_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF109; DIPEPTIDYL PEPTIDASE 9; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF19520; Dpp_8_9_N; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT   DOMAIN          22..136
FT                   /note="Dipeptidyl peptidase 8 /9 ,N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19520"
FT   DOMAIN          148..571
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          664..864
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   864 AA;  98447 MW;  0D82AD091F072A7A CRC64;
     MAATTEAPVA DRGDTVDMDD PAARFQVQKH SWEGLRNIIH GSRKYSGLIV NKAPHDFQFV
     QKTDESGPHS HRLYYLGMPY GSRENSLLYS EIPKKVRKEA LLLLSWKQML DHFQATPHHG
     VYSREEELLR ERKRLGVFGI TSYDFHSDSG LFLFQASNSL FHCRDGGKNG FMVSPMKPLE
     IKTQCTGPRM DPKICPADPA FFSFINNSDL WVANIETGEE RRLTFCHKGL SSVLEDPKSA
     GVATFVIQEE FDRFTGYWWC PSASWEGSDG LKTLRILYEE VDESEVEIIH VPSPALEERK
     TDSYRYPRTG SKNPKIALKL AEFQTDSEGK IVSAQEKELV QPFSSLFPKV EYIARAGWTR
     DGKYAWAMFL DRPQQRLQLV LLPPALFILA TESEEQRLAF ARAVPKNVQP YVVYEEVTNV
     WINVHDIFYP FPQSEGEEEL CFLRANECKT GFCHLYKVTA ILKPKGYDWS EPFSPGEDEF
     KCPIKEEIAL TSGEWEVLAR HGSKIWVNEE TKLVYFQGTK DTPLEHHLYV VSYESAGEIV
     RLTTPGFSHS CSMSQNFDMF VSHYSSVSTP PCVHVYKLSG PDGDPLHKQP RFWASMMEAA
     SCPPDYVPPE IFHFHTRADV RLYGMIYKPH AVQPGKKHPT VLFVYGGPQV QLVNNSFKGI
     KYLRLNTLAS LGYAVVVIDG RGSCQRGLRF EGALKNQMGQ VEIEDQVEGL QFVAEKYGFI
     DLSRVAIHGW SYGGFLSLMG LIHKPQVFKV AIAGAPVTVW MAYDTGYTER YMDIPENNQH
     GYEAGSVALH VEKLPNEPNR LLILHGFLDE NVHFFHTNFL VSQLIRAGKP YQLQIYPNER
     HSIRCPESGE HYEVTLLHFL QEYL
//