ID H0WX68_OTOGA Unreviewed; 1237 AA.
AC H0WX68;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
GN Name=NPHP3 {ECO:0000313|Ensembl:ENSOGAP00000007026.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007026.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000007026.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03061909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03061910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000007026; -.
DR Ensembl; ENSOGAT00000007849.2; ENSOGAP00000007026.2; ENSOGAG00000007842.2.
DR eggNOG; KOG1840; Eukaryota.
DR GeneTree; ENSGT00940000156398; -.
DR HOGENOM; CLU_007418_0_0_1; -.
DR InParanoid; H0WX68; -.
DR OMA; FKIHQKA; -.
DR TreeFam; TF314010; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0003283; P:atrial septum development; IEA:Ensembl.
DR GO; GO:0060027; P:convergent extension involved in gastrulation; IEA:Ensembl.
DR GO; GO:0071908; P:determination of intestine left/right asymmetry; IEA:Ensembl.
DR GO; GO:0071910; P:determination of liver left/right asymmetry; IEA:Ensembl.
DR GO; GO:0035469; P:determination of pancreatic left/right asymmetry; IEA:Ensembl.
DR GO; GO:0071909; P:determination of stomach left/right asymmetry; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0060993; P:kidney morphogenesis; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0048496; P:maintenance of animal organ identity; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0045494; P:photoreceptor cell maintenance; IEA:Ensembl.
DR GO; GO:2000095; P:regulation of Wnt signaling pathway, planar cell polarity pathway; IEA:Ensembl.
DR GO; GO:0072189; P:ureter development; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR Pfam; PF13424; TPR_12; 3.
DR Pfam; PF13176; TPR_7; 1.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 6.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT REPEAT 893..926
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1001..1034
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1043..1076
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1085..1118
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1127..1160
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1169..1202
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1203..1237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 24..111
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1209..1227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1237 AA; 141818 MW; 4A28EEAB59F37419 CRC64;
XLKKEYDIFR VSKNQELLSM GRREAKLDTE NKRLRAELQA LQKTYQKILR EKESALEAKY
QAMERAATFE HDRDKVKRQF KIFRETKENE IQDLLRAKRE LESKLQRLQA QGIQVFDPGE
SDSDDNCTDV TAAGTQCEYW TGGALGSEPS IGSMMQLQQS FRGPEFAHSS IDVEGPFANV
NRDDWDIAVA SLLQVTPLFS HSLWSNAVRC YLIYTDETQP EMDLFLKDYS PNLKRMCETM
GYFFHAIYFP IDVENQYLTV RKWEIEKSSL VILFIHLNLP SFLLEDCEEA FLKNTEGKPR
LIYHRLEDGK VTSDSVQQFI DQVSNLNKTN KAKIIDHSGE PAEGVYKTYI CVEKIIKQDI
LGFENTDLET KDLGSEDSIP DEDDFGDVLW DIHDEQEQME TFHQASNSAH ELGFEKYYQR
LNDLVAAPAP IPPLLVSGGP GSGKSLLLSK WIQLQQKNSP NTLILSHFVG RPMSTSSESS
LIIKRLTLKL MQHSWSVSAL TLDPAKLLEE FPRWLEKLSA RHQGSIIIII DSIDQVQQVE
KHMKWLIDPL PVNVRVIVSV NVETCPPAWR LWPTLHLDPL NPKDAKSIII AECHSVDITL
SKEQEKKLER HCRSATTCNA LYVTLCSKMI TRAGRAGNLD RILHQCSQCQ DTVSLYRLAL
RVIQESMAND ADKELMKRTL CLINVSHNGV SESELMELYP EMSWAVLTTL IHSLHKMCLL
TYGCGLLRFQ HLQAWEAVRL EYIDCPAVIS SYRQKLINYF TLQLSQDRVT WRSADELPWL
FQQQGSKQKL HDCLLNLFVS QNLYKRGHFA ELLSYWQFVG KDKSAMAAEY FDSLKQYEKN
CEGEENMICL ADLYETLGRF LKDLGLLSQA VVPLQRSLEI RETALDPDHP RVAQSLHQLA
SVYVQWKKFG NAEQLYKQAL EISENAYGAD HPHTARELEA LATLYQKQNK YEQAEHFRKK
SLKIHQKATR RKGNLYGFAL LRRRALQLEE LTLGKDTPDN ARTLNELGVL YYLQNNLETA
DQFLKRSLEM RERVLGPDHP DCAQSLNNLA ALCNEKKQYD KAEELYERAL DIRRRALAPD
HPSLAYTVKH LSVLYKKMGK LDKAVPLYEL AVEIRQKSFG PKHPSVATAL VNLAVLYSQM
KKHVEALPLY ERALKIYEDS LGRMHPRVGE TLKNLAVLSY EEGDFEKAAE LYKRAMEIKE
AETSLLGGKA PSRHSSSGDT YSLKPHSPNV FLNKDKD
//
