ID   H0WXJ8_OTOGA            Unreviewed;       747 AA.
AC   H0WXJ8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=DNA polymerase iota {ECO:0000313|Ensembl:ENSOGAP00000007185.2};
GN   Name=POLI {ECO:0000313|Ensembl:ENSOGAP00000007185.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007185.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000007185.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AAQR03057198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0WXJ8; -.
DR   STRING; 30611.ENSOGAP00000007185; -.
DR   Ensembl; ENSOGAT00000008034.2; ENSOGAP00000007185.2; ENSOGAG00000008030.2.
DR   eggNOG; KOG2095; Eukaryota.
DR   GeneTree; ENSGT00940000159487; -.
DR   HOGENOM; CLU_012348_9_0_1; -.
DR   InParanoid; H0WXJ8; -.
DR   OMA; GNCDVMT; -.
DR   TreeFam; TF324222; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd01703; PolY_Pol_iota; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.40.1170.60; -; 1.
DR   Gene3D; 6.10.250.1630; -; 2.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR   InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR   InterPro; IPR024728; PolY_HhH_motif.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001126; UmuC.
DR   PANTHER; PTHR46404; DNA POLYMERASE IOTA; 1.
DR   PANTHER; PTHR46404:SF1; DNA POLYMERASE IOTA; 1.
DR   Pfam; PF00817; IMS; 1.
DR   Pfam; PF11799; IMS_C; 1.
DR   Pfam; PF11798; IMS_HHH; 1.
DR   PIRSF; PIRSF036603; DPol_eta; 2.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR   PROSITE; PS50173; UMUC; 1.
PE   4: Predicted;
KW   DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT   DOMAIN          64..277
FT                   /note="UmuC"
FT                   /evidence="ECO:0000259|PROSITE:PS50173"
FT   REGION          501..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          582..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        507..521
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   747 AA;  83552 MW;  0D25B1A08FC1CDF2 CRC64;
     MEKGVEPEEG GSGEEEENEA WVMELEDLGA AGGSQGALGL EGPGSLPGFH DQVLPAGSFS
     SRVIAHLDLD CFYAQVEMIS NPELRDKPLG VQQKFSVVTC NYEARKFGVK KCMPVREAKE
     KCPQLVLVNG EDLTRYREMS YKVTELLKEF SPVVERLGFD ENFVDLTEMV EKRLQQLQSD
     ELSAVSVSGH VYNNQCINLD DILHVRLLVG SQIAAEMREA MYNQLGLTGC AGVASNKLLA
     KLVSGIFKPN QQTVLLPESC QDLIHSLNHI KEIPGIGYKT TKRLEALGIN SVHDLQTCSS
     KILVKELGMS VAHHIQKLSF GEDNSPVTPS GPPQSFSEED SFKKCSSEVE AKKKIEELLA
     SLLNRVCQDG RKPHTVRLTL RRYSSEKYCS RESRQCPIPS HVIQKLGRGN SDVMTPMIDI
     LMKLFRNMVN VKMPFHLTLL NVCFCNLKAS NAAKKGSIDY YLMPSLSTTS HPDKHGFKMK
     DTHMEDFSKD KEINHDFLQS GKIESTKTEE SPLDTTDFSK GKDNNESALC SLPEGVDQEV
     FKQLPVDIQE EILSEKCREK FQGKENLSCP LHASRGVLSF FSPKRTQDSP INPRNPLFSS
     KQASSVSSCE PGTSGLNSSS SSYRSSQKDY SYYLDNRLKG ERMSQGPKEP QRFQLPNTNP
     AVSVFHSLPN LQSEQLFSKN QTAGNCHKQT MASHHEGLTE NREQDSFDEK ITFPSDIDPQ
     VFYELPEDVQ MELLAEWKRR GPDFPIV
//