ID H0WXN1_OTOGA Unreviewed; 335 AA.
AC H0WXN1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Ankyrin repeat and SOCS box containing 1 {ECO:0000313|Ensembl:ENSOGAP00000007224.2};
GN Name=ASB1 {ECO:0000313|Ensembl:ENSOGAP00000007224.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007224.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000007224.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000256|ARBA:ARBA00005949}.
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DR EMBL; AAQR03144205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03144206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03144207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WXN1; -.
DR STRING; 30611.ENSOGAP00000007224; -.
DR Ensembl; ENSOGAT00000008079.2; ENSOGAP00000007224.2; ENSOGAG00000008075.2.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000153969; -.
DR HOGENOM; CLU_053981_0_0_1; -.
DR InParanoid; H0WXN1; -.
DR OMA; AYHHLEC; -.
DR OrthoDB; 5475985at2759; -.
DR TreeFam; TF331945; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0000151; C:ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0030539; P:male genitalia development; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03720; SOCS_ASB1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037331; ASB1_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24173:SF27; ANKYRIN REPEAT AND SOCS BOX PROTEIN 1; 1.
DR PANTHER; PTHR24173; ANKYRIN REPEAT CONTAINING; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50225; SOCS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 80..109
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 110..142
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 143..175
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 293..335
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 335 AA; 36872 MW; B08B7A4D65FBA6EF CRC64;
MAEGGGPDGR AGLGSAGPNL KEWLREQFCD HPLEHCEDTR LHDAAYVGDL QTLRSLLQEE
SYRSRINEKS VWCCGWLPCT PLRIAATAGH GSCVDFLIRK GAEVDLVDVK GQTALYVAVV
NGHLESAQIL LEAGADPNGS RHHRSTPVYH ASRVGRADIL QALIRYGADV DVNHHLTPDI
QPPFSRRLTS LVVCPLYISA AYHNLQCFRL LLLAGANPDF NCNGPVNTQG FYRGSPGCVM
DAVLRHGCEA AFVSLLVEFG ANLNLVKWES LGPEARGRRK VDPEALQVFK EAKSVPRTLL
SLCRVAVRRA LGKYRLHLIP SLPLPEPIKK FLLYE
//
