ID H0WXY9_OTOGA Unreviewed; 496 AA.
AC H0WXY9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Solute carrier family 19 member 3 {ECO:0000313|Ensembl:ENSOGAP00000007347.2};
GN Name=SLC19A3 {ECO:0000313|Ensembl:ENSOGAP00000007347.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007347.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000007347.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|PIRNR:PIRNR028739}; Multi-
CC pass membrane protein {ECO:0000256|PIRNR:PIRNR028739}.
CC -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC 2.A.48) family. {ECO:0000256|ARBA:ARBA00005773,
CC ECO:0000256|PIRNR:PIRNR028739}.
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DR EMBL; AAQR03030525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003784933.1; XM_003784885.2.
DR AlphaFoldDB; H0WXY9; -.
DR STRING; 30611.ENSOGAP00000007347; -.
DR Ensembl; ENSOGAT00000008211.2; ENSOGAP00000007347.2; ENSOGAG00000008209.2.
DR GeneID; 100956251; -.
DR KEGG; oga:100956251; -.
DR CTD; 80704; -.
DR eggNOG; KOG3810; Eukaryota.
DR GeneTree; ENSGT00950000183022; -.
DR HOGENOM; CLU_036909_0_1_1; -.
DR InParanoid; H0WXY9; -.
DR OMA; DIWACYA; -.
DR OrthoDB; 51626at2759; -.
DR TreeFam; TF313684; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0015234; F:thiamine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0031923; P:pyridoxine transport; IEA:Ensembl.
DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:Ensembl.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002666; Folate_carrier.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00806; rfc; 1.
DR PANTHER; PTHR10686; FOLATE TRANSPORTER; 1.
DR PANTHER; PTHR10686:SF37; THIAMINE TRANSPORTER 2; 1.
DR Pfam; PF01770; Folate_carrier; 1.
DR PIRSF; PIRSF028739; Folate_carrier; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|PIRNR:PIRNR028739, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|PIRNR:PIRNR028739}.
FT TRANSMEM 12..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 220..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 496 AA; 55364 MW; 25A8796FC36BB013 CRC64;
MDCYRPSPSN SWIYPTVILC LFGFFATMRP SEPFLIPYLS GPNKNLTTEE ITNEILPVWT
YSYLALLLPV FVLTDYVRYK PVIILQGVSF IITWLLLLFG QGVMSMQVVE FFYGMVTATE
VAYYAYIYSV VSPEHYQKVS GYCRSVTLVA YTAASVLAQL LVSLADLSYF YLNVITLVSV
STAFLFSLFL PMPKKSMFFH AKPSKEIKTS PSMSAVLAEP PEGETLGCGK RKSASEIPTA
PGSPSEAQLS SPAPKAETLQ VFVQWFRDLK ECYSSKHLFY WSLWWAFSTA GFNQVLNYVQ
ILWDYKAPLQ DSSIYNGAVE AIATFGGALA AFAVGYVKVN WDLLGELALA LFSVVSAGSL
LLMHYTANIW ACYAGYLIFK SSYMLLITIA VFQIAVNLSV ERYALVFGIN TFIALVIQTI
MTVIVVDPRG LNLPISIQFL VYGSYFAVIA GIFLMRSTYI IYSAKWLREE QSLATSQNAD
GPHPEEPRNT TTSTRL
//
