ID   H0WY90_OTOGA            Unreviewed;      1007 AA.
AC   H0WY90;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=Hermansky-Pudlak syndrome 3 protein homolog {ECO:0000256|PIRNR:PIRNR037473};
GN   Name=HPS3 {ECO:0000313|Ensembl:ENSOGAP00000007462.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007462.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000007462.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Involved in early stages of melanosome biogenesis and
CC       maturation. {ECO:0000256|PIRNR:PIRNR037473}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
CC       {ECO:0000256|PIRNR:PIRNR037473}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037473}.
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DR   EMBL; AAQR03063346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03063347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03063348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03063349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03063350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03063351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0WY90; -.
DR   STRING; 30611.ENSOGAP00000007462; -.
DR   Ensembl; ENSOGAT00000008337.2; ENSOGAP00000007462.2; ENSOGAG00000008334.2.
DR   eggNOG; ENOG502QRQB; Eukaryota.
DR   GeneTree; ENSGT00390000015458; -.
DR   HOGENOM; CLU_011989_0_0_1; -.
DR   InParanoid; H0WY90; -.
DR   OMA; LCIQNTE; -.
DR   TreeFam; TF324432; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0031084; C:BLOC-2 complex; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006996; P:organelle organization; IEA:Ensembl.
DR   GO; GO:0043473; P:pigmentation; IEA:Ensembl.
DR   InterPro; IPR017216; HPS3.
DR   InterPro; IPR029438; HPS3_C.
DR   InterPro; IPR029437; HPS3_N.
DR   PANTHER; PTHR28633; HERMANSKY-PUDLAK SYNDROME 3 PROTEIN; 1.
DR   PANTHER; PTHR28633:SF1; HERMANSKY-PUDLAK SYNDROME 3 PROTEIN; 1.
DR   Pfam; PF14763; HPS3_C; 1.
DR   Pfam; PF14761; HPS3_N; 1.
DR   PIRSF; PIRSF037473; BLOC-2_complex_Hps3; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR037473};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT   DOMAIN          3..478
FT                   /note="BLOC-2 complex member HPS3 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14761"
FT   DOMAIN          497..1004
FT                   /note="BLOC-2 complex member HPS3 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14763"
SQ   SEQUENCE   1007 AA;  113587 MW;  216E0485E0E6DB76 CRC64;
     MVQLYNLHPF GSQQVVPCKL EPERFCGGGR DALFVAAGCK VEAFAVAGQE LCQPRCSFST
     LGRVLRMAYS EAGDYLVAIE EKNKATFLRA YVNWRSKRTE NARVCIRMVG HDVEASFRET
     FRDQMSIVEM PLSEAPLCIS CCPVKGDLLV GCTNKLVLFS LKRHTIDEEF SLLDFERSLI
     IHIDNIMPVE ISYCVGHVGV MSDLEVLILK LESDAKIAER VNHHSRKASN PVKQTEKGIN
     NEISQLESDD FVICPKPMEL LGKKSEQSGL SITLESTGLA DEKLQYVHVQ HLLYRRFAPD
     ISAYVLPDDI KLHSLQLLPI YQTGTFDSKL EEKVPRKEPR NLAFQIPRII WLSILTVVNR
     LGSCRWRFLS GGAAVLITTD DNQALTVGSL GSFTVQKQPG VVERGRGYMD TTLKACPPIS
     MDVCALRIQL FIGLKAICHF KNHVILLTKA EPEAIPERRD SPRRLLSRKD TSGKSKIPPV
     AEAGWNLYIV NTVSPVQLYK EMVDYSNTYK TAKTQSCIHL LSEAHLLVRA ALMDASQLEP
     GEKAELLEAF RESCAHLGDC YNFLPSRLDT QHSHLTLPYY KMSGLSLAEV LARVDWTVED
     MSQKYERGLI FYINHSLYEN LDEELTKELA AKVVQMFYVA EPKQLPHVLC SPSVKNINPS
     TAMSYLRKLD VSGLSSILLT LTKAAVALKM GDLDVHRNEM KSHSEMKLVC GFILEPRLLI
     QQRKGQVIPT ELANHLKETQ PALLVAAVLG LQKNNKIGIE EADSFFKVLC VKDEDTIPQL
     LVDFWEAQLV ACLPDVVLQE LFFKLISQYI WRLSKRQPPD TTPLRTSEDL INACGHYGLI
     YPWVHVLMSS DSLADEYYTG DLSKLQSLIC GPSFDIASII PFLEPLSEDT VAGLSVHVLC
     RTRLKEHEQC LDVLLERCPE AVIPYANHEL KEENRTLWWK KLLPELCQRI KHGGEKYRLY
     LSLLKETLSV VAVELELKDF LNVLPEDGTA AFFLPYLLYC SRKKSLT
//