ID H0WY95_OTOGA Unreviewed; 1067 AA.
AC H0WY95;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=ferroxidase {ECO:0000256|ARBA:ARBA00013107};
DE EC=1.16.3.1 {ECO:0000256|ARBA:ARBA00013107};
GN Name=CP {ECO:0000313|Ensembl:ENSOGAP00000007467.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007467.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000007467.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O;
CC Xref=Rhea:RHEA:11148, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.16.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001830};
CC -!- SIMILARITY: Belongs to the multicopper oxidase family.
CC {ECO:0000256|ARBA:ARBA00010609}.
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DR EMBL; AAQR03063352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03063353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03063354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03063355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WY95; -.
DR STRING; 30611.ENSOGAP00000007467; -.
DR Ensembl; ENSOGAT00000008342.2; ENSOGAP00000007467.2; ENSOGAG00000008337.2.
DR eggNOG; KOG1263; Eukaryota.
DR GeneTree; ENSGT00940000155866; -.
DR HOGENOM; CLU_005569_0_0_1; -.
DR InParanoid; H0WY95; -.
DR OMA; HVTDHIS; -.
DR TreeFam; TF329807; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0004322; F:ferroxidase activity; IEA:Ensembl.
DR GO; GO:0004602; F:glutathione peroxidase activity; IEA:Ensembl.
DR GO; GO:0047066; F:phospholipid-hydroperoxide glutathione peroxidase activity; IEA:Ensembl.
DR GO; GO:0051087; F:protein-folding chaperone binding; IEA:Ensembl.
DR GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006878; P:intracellular copper ion homeostasis; IEA:Ensembl.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; IEA:Ensembl.
DR CDD; cd11021; CuRO_2_ceruloplasmin; 1.
DR CDD; cd04224; CuRO_3_ceruloplasmin; 1.
DR CDD; cd11022; CuRO_4_ceruloplasmin; 1.
DR CDD; cd04225; CuRO_5_ceruloplasmin; 1.
DR CDD; cd11012; CuRO_6_ceruloplasmin; 1.
DR Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 5.
DR InterPro; IPR048236; Ceruloplasmin-like_CuRO_5.
DR InterPro; IPR011707; Cu-oxidase-like_N.
DR InterPro; IPR001117; Cu-oxidase_2nd.
DR InterPro; IPR011706; Cu-oxidase_C.
DR InterPro; IPR033138; Cu_oxidase_CS.
DR InterPro; IPR002355; Cu_oxidase_Cu_BS.
DR InterPro; IPR008972; Cupredoxin.
DR PANTHER; PTHR46806:SF7; COAGULATION FACTOR VIII; 1.
DR PANTHER; PTHR46806; F5/8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00394; Cu-oxidase; 1.
DR Pfam; PF07731; Cu-oxidase_2; 1.
DR Pfam; PF07732; Cu-oxidase_3; 2.
DR SUPFAM; SSF49503; Cupredoxins; 6.
DR PROSITE; PS00079; MULTICOPPER_OXIDASE1; 3.
DR PROSITE; PS00080; MULTICOPPER_OXIDASE2; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00023065}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1067
FT /note="ferroxidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003545171"
FT DOMAIN 91..202
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07732"
FT DOMAIN 223..357
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF00394"
FT DOMAIN 809..869
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07732"
FT DOMAIN 956..1060
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07731"
SQ SEQUENCE 1067 AA; 121579 MW; BDA854871D0F85BF CRC64;
MKISILGIFL FFYSTPAWAK EKHYYIGIIE TPWNYASDSG EKKLISVDTE HSNIYLQNGP
DRIGRIYKKA LYLQYTDGTF SKTVEKPVWL GFLGPIIKAE TGEKVYVHLK NFASRPYTFH
AHGMTYYKEH EGAIYPDNTT GFQKADDKVY PGEQYTYTLH ATEEQSPGEA DSNCVTRIYH
SHIDAPKDIA SGLIGPLIIC KKDSLDEGKE KNIDREFVVM FSVVDENLSW YIDDNIKTYC
SEPEKVDKDS EDFQESNRMH SVNGYTFGSL PGLSMCTEDR VKWYLFGMGN EVDVHAAFFH
GQALTNKNYR IDTVNLFPAT LFDALMVAQS PGEWMLSCQN LNHLKAGLQA FFQVQDCNKS
SPKDDISGKQ VRHYYIAAEE MIWNYAPSGI DAFTKENLTA PESDSKVFFE QGATRIGGSY
KKLVYREYTD DSFTSRKERG PEEEHLGILG PVIWAEVGDT IRVTFRNKGA YPLSMEPTGV
RFSKNNEGTY YYSSQGGSTP PPSASYVAPK ETFTYEWSVP EEVGPTYADP VCLARMYYSA
VDPTKDIFTG LIGPMKICKK GSLHANGRQK GVDKEFYLFP TVFDENESLL LDDNVRMFTT
APDQVDKEDG DFQESNKMHS MNGFMYGNQP GLNMCQGDSV VWYLFSAGNE ADVHGIYFSG
NTYLSRGERR DTANLFPQTS LTLLMQPDSK VTTPGTFDVE CLTTDHYAGG MKQKYTVQQC
GRLSEDSSQY RGERTYYVAA VEVEWDYSPR REWEKELHHL QEQNVSNAFL DKEEFFIGSK
YKKVVYRQYT DSTFRVPVER KAEEEHLGIL GPQLHADVGD KVKIIFKNMA TRPYSIHAHG
VKTESSTVTP TLPGETRTYI WEIPERSGAG TEDSACIPWA YYSTVDQVKD LYSGLIGPLI
VCRKPYFTVF NPYKKMEFSL LFLVFDENES WYLDDNIKTY SDHPEKVNKD SDEFIESNKM
HAINGRMFGN LQGLTMHVGD EVNWYLMGMG NEIDLHTVHF HGHSFRYKHR GVYSSDVFDI
FPGTYQTLEM FPREPGIWLL HCHVTDHVHA GMETTYTVLP NAETKSG
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