GenomeNet

Database: UniProt
Entry: H0WYG7_OTOGA
LinkDB: H0WYG7_OTOGA
Original site: H0WYG7_OTOGA 
ID   H0WYG7_OTOGA            Unreviewed;       630 AA.
AC   H0WYG7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 43.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN   Name=GLB1 {ECO:0000313|Ensembl:ENSOGAP00000007553};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007553, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000007553}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000007553}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
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DR   EMBL; AAQR03005636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03005637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03005638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03005639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03005640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03005641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03005642; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03005643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03005644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03005645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0WYG7; -.
DR   STRING; 30611.ENSOGAP00000007553; -.
DR   Ensembl; ENSOGAT00000008435; ENSOGAP00000007553; ENSOGAG00000008431.
DR   eggNOG; KOG0496; Eukaryota.
DR   eggNOG; COG1874; LUCA.
DR   GeneTree; ENSGT00390000006586; -.
DR   InParanoid; H0WYG7; -.
DR   OMA; GWGKGIV; -.
DR   TreeFam; TF314816; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0044262; P:cellular carbohydrate metabolic process; IEA:Ensembl.
DR   Gene3D; 2.60.120.260; -; 2.
DR   InterPro; IPR026283; B-gal_1-like.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 1.
DR   Pfam; PF13364; BetaGal_dom4_5; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PIRSF; PIRSF006336; B-gal; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Glycosidase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT   DOMAIN       16    331       Glyco_hydro_35. {ECO:0000259|Pfam:
FT                                PF01301}.
FT   DOMAIN      523    592       BetaGal_dom4_5. {ECO:0000259|Pfam:
FT                                PF13364}.
FT   ACT_SITE    163    163       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
FT   ACT_SITE    243    243       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
SQ   SEQUENCE   630 AA;  70777 MW;  2AC5D255C5D9123C CRC64;
     NASLKTFKID YSRDRFLKDG QPFRYISGSI HYSRLPRFYW KDRLLKMKMA GLNAIQTYVP
     WNFHEPQPGK YQFSEDHDVE YFIQLAHELG LLVILRPGPY ICAEWDMGGL PAWLLEKESM
     ILRSSDPDYL AAVDKWLGVL LPKMKPLLYQ NGGPIISVQV ENEYGSYFTC DHDYMRFLLK
     RFRYYLGDDV VLFTTDGIFE KYLNCGALQG LYATVDFGTG VNITAAFKLQ RKSEPKGPLI
     NSEFYTGWLD HWGQPHSTVK TEDVAFSLFD ILARGASVNL YMFTGGTNFA YWNGANIPYS
     AQPTSYDYDA PLSEAGDLTE KYFALRSVIQ KFKETPEGPI PPSTPKFAYG KVALKKLKTV
     EAALDILCPS GPIKSLYPLK FVQLKQYFGF VLYRTTLPRD CNTPTPLSSP FNGVHDRAYV
     SVDGVPQGIL ARSTVLSLNI TGKAGATLDL LVENMGRVNY GKYIKDFKGL VSNLTLGSSI
     LMGWMMFPLN TEDAVRSQLG HWGGEDVRQH GKAPSSSNYT LPAFYVGNFS IYSGIPDLPQ
     DTFIQFPGWS KGQVWINGFN LGRYWPTQGP QMTLFVPQHI LTTSAPNTVI VLELEHAPCQ
     DNDTEPCTVA FVDKPVISGT MAHSLPLKPV
//
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