ID H0WZM8_OTOGA Unreviewed; 477 AA.
AC H0WZM8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Calcium uptake protein 1, mitochondrial {ECO:0000256|ARBA:ARBA00040181};
GN Name=MICU1 {ECO:0000313|Ensembl:ENSOGAP00000008057.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000008057.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000008057.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion intermembrane
CC space {ECO:0000256|ARBA:ARBA00004569}.
CC -!- SIMILARITY: Belongs to the MICU1 family. MICU1 subfamily.
CC {ECO:0000256|ARBA:ARBA00038333}.
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DR EMBL; AAQR03019011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03019012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03019013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03019014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03019015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03019016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03019017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03019018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03019019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03019020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WZM8; -.
DR STRING; 30611.ENSOGAP00000008057; -.
DR Ensembl; ENSOGAT00000008991.2; ENSOGAP00000008057.2; ENSOGAG00000008987.2.
DR eggNOG; KOG2643; Eukaryota.
DR GeneTree; ENSGT00950000183079; -.
DR HOGENOM; CLU_027103_3_1_1; -.
DR InParanoid; H0WZM8; -.
DR OMA; GGPMYMT; -.
DR TreeFam; TF313815; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:1990246; C:uniplex complex; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0036444; P:calcium import into the mitochondrion; IEA:Ensembl.
DR GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR GO; GO:0051561; P:positive regulation of mitochondrial calcium ion concentration; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
DR GO; GO:1900069; P:regulation of cellular hyperosmotic salinity response; IEA:Ensembl.
DR CDD; cd16173; EFh_MICU1; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039800; MICU1/2/3.
DR PANTHER; PTHR12294:SF1; CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12294; EF HAND DOMAIN FAMILY A1,A2-RELATED; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00022792};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00022792};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 220..255
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 410..445
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 55..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 477 AA; 54581 MW; BE0CCDE5637AE834 CRC64;
MFRLNSLSAL AELAVGSRWY HGGSHPTQTR RRLMMVAFLG ASAVTASTGL LWKRSRAHAE
SPPSVNNLKT EIGDKGKNKD EGEVCNHEKK TADLEPPPEE KKKKRSGFRD RKVMEYENRI
RAYSTPDKIF RYFATLKVIN EPGETEVFMT PEDFVRSITP NEKQPEHLGL DQYIIKRFDG
KKISQEREKF ADEDSIFYTL GECGLISFSD YIFLTTVLST PQRNFEIAFK MFDLNGDGEV
DMEEFEQVQS IIRSQTSMGM RHRDRPTTGN TLKSGLCSAL TTYFFGADLK GKLTIKNFLE
FQRKLQHDVL KLEFERHDPV DGRITERQFG GMLLAYSGVQ SKKLTAMQKQ LKKHFKEGKG
LTFQEVENFF TFLKNINDVD TALSFYHMAG ASLDKVTMQQ VARTVAKVEL SDHVCDVVFA
LFDCDGNGEL SNKEFVSIMK QRLMRGLEKP KDMGFTRLMQ AMWKCAQETA WDFALPK
//
