ID H0X0H5_OTOGA Unreviewed; 480 AA.
AC H0X0H5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=2-phosphoxylose phosphatase 1 {ECO:0000256|ARBA:ARBA00040357};
DE AltName: Full=Acid phosphatase-like protein 2 {ECO:0000256|ARBA:ARBA00041499};
GN Name=PXYLP1 {ECO:0000313|Ensembl:ENSOGAP00000008414.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000008414.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000008414.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-
CC beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1->3)-
CC beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:56512, Rhea:RHEA-COMP:12573, Rhea:RHEA-
CC COMP:14559, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:132093,
CC ChEBI:CHEBI:140495; Evidence={ECO:0000256|ARBA:ARBA00036311};
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR EMBL; AAQR03062646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062648; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062649; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003789492.1; XM_003789444.2.
DR AlphaFoldDB; H0X0H5; -.
DR Ensembl; ENSOGAT00000009397.2; ENSOGAP00000008414.2; ENSOGAG00000009393.2.
DR GeneID; 100946087; -.
DR KEGG; oga:100946087; -.
DR CTD; 92370; -.
DR GeneTree; ENSGT00390000016324; -.
DR HOGENOM; CLU_033855_1_0_1; -.
DR OrthoDB; 3403603at2759; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567:SF125; 2-PHOSPHOXYLOSE PHOSPHATASE 1; 1.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
SQ SEQUENCE 480 AA; 55295 MW; 31321947D6459D60 CRC64;
MLFRNRFLLL LALAALLAFL SLSLQFFHLI PVSTAKNGVS SKSRKRIMPD PVTEPPVTDP
IYEALWYCNI PSVAERTMEG HAPHHFKLVS VNVFIRHGDR YPLYVIPKTK RPEIDCTLVA
NRKPYHPKLE AFVSHMSKGS GASFESPLKG LPLYPNHPLC EMGELTQTGV VQHLQNGQLL
RDVYLKKHKL LPSDWATDQL YLETTGKSRT LQSGLALLYG FLPDFDWKKI YFRHQPSALF
CSANCYCPTR NQYLEKEQRR QYLLRLKNSQ LERTYGEMAK IVDVPTKQLR AANPVDSMLC
HFCHNVSFPC TRNGCIGMEH FKVIKTHQIE DERERREKKL YLGYSLLGAH PILNQTINRM
QRAAEGRKEE IFALYSAHDV TLSPVLSALG LSEARFPRFA ARLIFELWQD REKPGEHAVR
ILYNGVDVTF HTSFCRDHQK RSPKPMCPLE NLVHFVKRDM FVALDSSSTN YYDACHREGF
//
