ID   H0X0J8_OTOGA            Unreviewed;       477 AA.
AC   H0X0J8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Peripherin {ECO:0000313|Ensembl:ENSOGAP00000008444.2};
GN   Name=PRPH {ECO:0000313|Ensembl:ENSOGAP00000008444.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000008444.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000008444.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   EMBL; AAQR03104377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0X0J8; -.
DR   STRING; 30611.ENSOGAP00000008444; -.
DR   Ensembl; ENSOGAT00000009434.2; ENSOGAP00000008444.2; ENSOGAG00000009430.2.
DR   eggNOG; ENOG502QPSH; Eukaryota.
DR   GeneTree; ENSGT00940000160203; -.
DR   HOGENOM; CLU_012560_7_4_1; -.
DR   InParanoid; H0X0J8; -.
DR   OMA; THSRKMV; -.
DR   TreeFam; TF330122; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR006821; Intermed_filament_DNA-bd.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR   PANTHER; PTHR45652:SF14; PERIPHERIN; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF04732; Filament_head; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT   DOMAIN          103..413
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          453..477
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          93..255
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          311..391
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        14..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   477 AA;  54392 MW;  A9452F3EC4C574F1 CRC64;
     CPSSAAMSHH PSGLRAGVSS TSYRRTFGPP PSLSPGAFSY SSSSRFSSSR LLGSASPSYS
     VRLGSFRGPR AGAGALLRLP SERLDFSMAE ALNQEFLATR SNEKQELQEL NDRFANFIEK
     VRFLEQQNAA LRGELSQARG QEPARADQLC QQELRELRRE LELLGRERDR VQVERDGLAE
     DLAALKQRLE EEMRKREDAE HNLVLFRKDV DDATLSRLEL ERKIESLMDE IEFLKKLHEE
     ELRDLQMSVE SQQVQQVEVE ATVKPELTAA LRDIRAQYES IAAKNLQEAE EWYKSKYADL
     SDAANRNHEA LRQAKLEMNE SRRQIQSLTC EVDGLRGTNE ALLRQLRELE EQFALEAGGY
     QAGAARLEEE LRQLKEEMAR HLREYQELLN VKMALDIEIA TYRKLLEGEE SRISVPVHSF
     ASLNIKTTVP EVEPSQDSHS RKMVLIKTIE TRDGEQVVTE SQKEQRSELD KSSTHSY
//