ID H0X0Q9_OTOGA Unreviewed; 590 AA.
AC H0X0Q9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=MX dynamin like GTPase 1 {ECO:0000313|Ensembl:ENSOGAP00000008517.2};
GN Name=MX1 {ECO:0000313|Ensembl:ENSOGAP00000008517.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000008517.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000008517.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR EMBL; AAQR03141271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141274; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141275; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X0Q9; -.
DR STRING; 30611.ENSOGAP00000008517; -.
DR Ensembl; ENSOGAT00000009519.2; ENSOGAP00000008517.2; ENSOGAG00000009515.2.
DR eggNOG; KOG0446; Eukaryota.
DR GeneTree; ENSGT00940000155686; -.
DR HOGENOM; CLU_008964_8_0_1; -.
DR InParanoid; H0X0Q9; -.
DR OMA; FHKWSAV; -.
DR TreeFam; TF331484; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0070106; P:interleukin-27-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0045071; P:negative regulation of viral genome replication; IEA:Ensembl.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF217; INTERFERON-INDUCED GTP-BINDING PROTEIN MX1; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU003932};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003932};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 67..341
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
SQ SEQUENCE 590 AA; 67401 MW; 58875B1FF632597D CRC64;
MVLSQVGIAE PDSSFVADLQ LPYGDVNMAE KNQASGAENN LYNQYEEKVR PCIDLIDSLR
ALGVEQDLAL PAIAVIGDQS SGKSSVLEAL SGVALPRGSG IVTRCPLVLK LKKLVNKDEW
RGKVSYQDLE IEISDASEVE KEINKGKDPT FGLSHWMPGE ELISLEISSP HVPDLTLIDL
PGITRVAVGN QPADIGRQIK KLIKKYITKQ ETINLVVVPS NVDIATTEAL SMAQEVDPEG
DRTIGILTKP DLVDKGTEDK VVDVVRNLVC HLKKGYMIVK CRGQQDIQDQ LSLAEALQRE
KAFFEDHPYF RRLWFTGILT KPDLVDKGTE VCLYFLQKSL PYLENQIKES HQKITEELQK
YGVDIPDDEN EKMFFLIEKI NAFNQDIIAL MEGEEIVGED DTRLFTKLRN EFRKWSILIE
NNFQDSYEII SKKIYKFENQ YRGRELPGFV NYKTFESIVK QQIKTLEEPA IDMLHVVTAD
MVRMAFTNVS TKSFEEFFNL HRTTKSKIED IRIEKEKEAE KSIRLHFQME QIVYCQDQAY
RGALQRVREE DMEEEKKSKK FGSVNLQKLS ELSQESSMAE IFQHLMAYHQ
//
