ID H0X0W8_OTOGA Unreviewed; 502 AA.
AC H0X0W8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Interferon regulatory factor 5 {ECO:0000313|Ensembl:ENSOGAP00000008593.2};
GN Name=IRF5 {ECO:0000313|Ensembl:ENSOGAP00000008593.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000008593.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000008593.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03068571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03068572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X0W8; -.
DR STRING; 30611.ENSOGAP00000008593; -.
DR Ensembl; ENSOGAT00000009608.2; ENSOGAP00000008593.2; ENSOGAG00000009608.2.
DR eggNOG; ENOG502QSKM; Eukaryota.
DR GeneTree; ENSGT00940000159926; -.
DR HOGENOM; CLU_031544_0_0_1; -.
DR InParanoid; H0X0W8; -.
DR OMA; QGPWAPT; -.
DR TreeFam; TF328512; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0002720; P:positive regulation of cytokine production involved in immune response; IEA:Ensembl.
DR GO; GO:0032481; P:positive regulation of type I interferon production; IEA:Ensembl.
DR GO; GO:0032495; P:response to muramyl dipeptide; IEA:Ensembl.
DR GO; GO:0032494; P:response to peptidoglycan; IEA:Ensembl.
DR CDD; cd00103; IRF; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR InterPro; IPR019471; Interferon_reg_factor-3.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR PANTHER; PTHR11949:SF10; INTERFERON REGULATORY FACTOR 5; 1.
DR Pfam; PF00605; IRF; 1.
DR Pfam; PF10401; IRF-3; 1.
DR PRINTS; PR00267; INTFRNREGFCT.
DR SMART; SM00348; IRF; 1.
DR SMART; SM01243; IRF-3; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51507; IRF_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 14..122
FT /note="IRF tryptophan pentad repeat"
FT /evidence="ECO:0000259|PROSITE:PS51507"
FT REGION 128..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 502 AA; 56154 MW; 234FA66461E4439B CRC64;
MNQPTPGASA PPRRVRLKPW LVAQVNSGQY PGLQWVNGEK KFFYIPWRHA TRHGPSQDGD
NTIFKSYTHH SDTQTTRVDE ADPAKWKANL RCALNKSRDF CLFYDGPRDM PPQPYKIYEV
CSNGSAPTGI RPGPIHSRRA GEEEEEEEEE LQRMLPGLTI TEAVPPGRPM VPFSLPKEEV
KWPPTLQPPG VLGPGAPDPN LLAPPPVAPT GFGDIASEVL PSLEPGPLGA SLPPAGQLLP
DLLISPHMLP LTDLEIKFQY RGRPPQALTI SNPNGCRLFY SQLEATQEQV ELFGPVSLEQ
VRFPSPEDIP SDKQRFYTNQ LLDVLDRGLI LQLQGQDLYA IRLCQCKVFW SGPCASANGS
CPNPIQREVK TKLFSLEHFL NELILFQKGQ TNTPPPFEIF FCFGEEWPDP KPREKKLITV
QVVPVAARLL LEMFSGELSW SADSIRLQIS NPDLKDRMVE QFKELHHIWH TQQRLQPMAQ
APPVAGLGAG QGPWPMHPVS MQ
//
