ID H0X103_OTOGA Unreviewed; 622 AA.
AC H0X103;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Cell division cycle 14A {ECO:0000313|Ensembl:ENSOGAP00000008638.2};
GN Name=CDC14A {ECO:0000313|Ensembl:ENSOGAP00000008638.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000008638.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000008638.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001512};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001482};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class CDC14 subfamily. {ECO:0000256|ARBA:ARBA00007315}.
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DR EMBL; AAQR03022720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03022721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03022722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03022723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03022724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03022725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03022726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03022727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03022728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03022729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012657104.1; XM_012801650.1.
DR AlphaFoldDB; H0X103; -.
DR STRING; 30611.ENSOGAP00000008638; -.
DR Ensembl; ENSOGAT00000009659.2; ENSOGAP00000008638.2; ENSOGAG00000009649.2.
DR GeneID; 100961385; -.
DR CTD; 8556; -.
DR eggNOG; KOG1720; Eukaryota.
DR GeneTree; ENSGT00940000155899; -.
DR HOGENOM; CLU_017787_2_2_1; -.
DR InParanoid; H0X103; -.
DR OMA; EDMKLHT; -.
DR OrthoDB; 9871at2759; -.
DR TreeFam; TF101053; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:1902636; C:kinociliary basal body; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0032426; C:stereocilium tip; IEA:Ensembl.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR CDD; cd14499; CDC14_C; 1.
DR CDD; cd17657; CDC14_N; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR044506; CDC14_C.
DR InterPro; IPR029260; DSPn.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR23339:SF77; DUAL SPECIFICITY PROTEIN PHOSPHATASE CDC14A; 1.
DR PANTHER; PTHR23339; TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR Pfam; PF00782; DSPc; 1.
DR Pfam; PF14671; DSPn; 1.
DR SMART; SM00195; DSPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 179..336
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 261..323
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 398..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 69373 MW; 733CB6CC77E8DD8E CRC64;
MAAESGELIG ACEFMKDRLY FATLRNRPKS TVNTHYFSID EELVYENFYA DFGPLNLAMV
YRYCCKLNKK LKSYSLSRKK IVHYTCFDQR KRANAAFLIG AYAVIYLKKT PEEAYRALLS
GSNPPYLPFR DASFGNCTYS LTILDCLQGI RKGLQHGFFD FETFDVDEYE HYERVENGDF
NWIVPGKFLA FSGPHPKSKI ENGYPLHAPE AYFPYFKKHN VTAIVRLNKK IYEAKRFTDA
GFEHYDLFFI DGSTPSDNIV RRFLNICENT DGAIAVHCKA GLGRTGTLIA CYVMKHYRFT
HAEIIAWIRI CRPGSIIGPQ QHFLEEKQAS LWVQGDIFRS KLKSRPSSEG SINKILSSLD
DMSISGNLSK MQSLERFGEN NLEDDEDIEM KNSITQGDKL RALKSQRQPR TSPSCAFRSD
DMKGHPRAMS QPFRLSSSPQ GSVPILKTSK VGLSPSATAK RINRVSLSSG PSIRSFSINS
RLASSLGNLN AATDDPENRK TSSPSKAGFA ANSFTNLLNG SSQQTTRNYP EVNNNQCSSG
GGGANVNSSP GLHSAKTEAH TSIPRPSYTG LSSSSARFLS RSIPVSFQTP PLGPPNPERS
FCALPSQLRL PPQKFNSSKE AF
//
