ID H0X1B6_OTOGA Unreviewed; 1221 AA.
AC H0X1B6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Multimerin 1 {ECO:0000313|Ensembl:ENSOGAP00000008777.2};
GN Name=MMRN1 {ECO:0000313|Ensembl:ENSOGAP00000008777.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000008777.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000008777.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03071124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03071125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03071126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X1B6; -.
DR STRING; 30611.ENSOGAP00000008777; -.
DR Ensembl; ENSOGAT00000009816.2; ENSOGAP00000008777.2; ENSOGAG00000009811.2.
DR eggNOG; ENOG502QTYP; Eukaryota.
DR GeneTree; ENSGT01030000234633; -.
DR HOGENOM; CLU_011016_0_0_1; -.
DR InParanoid; H0X1B6; -.
DR OMA; NCTVKLV; -.
DR TreeFam; TF336041; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:1990972; C:multimerin complex; IEA:Ensembl.
DR GO; GO:0031091; C:platelet alpha granule; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0033627; P:cell adhesion mediated by integrin; IEA:Ensembl.
DR GO; GO:0061045; P:negative regulation of wound healing; IEA:Ensembl.
DR GO; GO:1901731; P:positive regulation of platelet aggregation; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR PANTHER; PTHR15427:SF3; MULTIMERIN-1; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07546; EMI; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SMART; SM00181; EGF; 1.
DR SMART; SM00179; EGF_CA; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS50871; C1Q; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1221
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003545002"
FT DOMAIN 195..270
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 1034..1070
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1089..1221
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 25..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 815..842
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 27..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1060..1069
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1221 AA; 137707 MW; 74EC22DFA68D3DB5 CRC64;
MKGARLFVLL SSLWSGGIGL PDSRHSWTTP EGKNFQETRT SASVSPNKTP TFQMLPSTQM
ASADVTTTPE ARTSEESLLK STLPLSETSG PPQVRNQTVT PTRKMEEGVV KLRSLALPTN
STVKFSPGEE SVVLSNATLK FLQSFAQKSS RQAIPPNSVG GLGNRSPRET YLSRGDSRPS
QRTDYQKPSF ETTRGKNWCA YVHTRLSPTV VLDNQVTYIP GGRGSCGWTG GSCPQRSQKI
SNPVYRMQHK IVTSLDWRCC PGYSGPKCQP KGQEQQQLIH TDQAESHAAI GRGSAEQRQP
QDCGDPAVMQ KMTDQMNHQA TKLTVLQKKI ENISLAVNEI RNTYTSLEGK ISEDKGREFQ
SFLKGLKSKS INELVKDIVR EQFKIFQSDM QETVAQLFKT VSSLSQDLEN TRQIIQTVNE
SVVSIAVQRT SVLMQEKRPT LTDLVELRDD IVNIRQEMTV TCEKPVKELE EKQSHLESAL
QQERTRNLLY YESFNRTLSK MREVHERLLS TEKVTGQKNV PAVPSAANNV TEYLSTLQEN
MRKQGVMLLQ MIDDLHVQDS KINNLTVALD VEKESVRDEC EAMLSKCRND FKFQLKDTEE
NVHVLNQTLA EILFPMDNKM DKMSEQLNDL TYDMEILQPL LEQGASLRQI TTHAQSKEEA
VTRKKLETLT IAVNSLNFLI RELTKRHNLL KNEVQSHGEV LERRINENAL EMEDGLNKTM
TIINNAIDFI QDNYVLKETI NSIKYTPEAH QKCTKDMETI LTFISQFQHL NESIQILVND
NQRYNFVLQV ARALADIPKD GKLSQSNFQK IYQTFNETTS QVRKYQQNIS RLEEKILSAS
EISKKFETRL QGIESKVTQT LIPYYISLKK DKKDDAATNE RNQALQLQVL NSRFKALEAK
SIYLSINFSS LNKTLYEVLA TCHNASASIS ELNATIPKWV KGSLPDILLL QKGLTEFVEP
IIEIKTQAVL SNLTWYIDRS LSGNLANVIK SQKQVKSVLK KPNALKKPTV NLTTILIGRT
QRNTDNVIYP VTEEYSGCSR FPCQNGGTCI DGRASFTCAC RHPFTGTNCT IKLVEENALA
PDFSKGSYRY APMVAFFTSH TYGMTTPGPI RFNNLDINYG ASYTPRTGKF RVPYLGVYVF
KYTIESFSAH ISGFLVVDGK DKLAFESESI NSEVHCDRVV TGDALLELNY GQEVWLRLVK
GTIPAKFPPA TTFSGYLLYR T
//
