ID H0X1C5_OTOGA Unreviewed; 2624 AA.
AC H0X1C5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Filamin C {ECO:0000313|Ensembl:ENSOGAP00000008789.2};
GN Name=FLNC {ECO:0000313|Ensembl:ENSOGAP00000008789.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000008789.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000008789.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR EMBL; AAQR03068579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000008789; -.
DR Ensembl; ENSOGAT00000009831.2; ENSOGAP00000008789.2; ENSOGAG00000009823.2.
DR eggNOG; KOG0518; Eukaryota.
DR GeneTree; ENSGT00940000153588; -.
DR HOGENOM; CLU_000783_0_0_1; -.
DR InParanoid; H0X1C5; -.
DR OMA; YPVMAGK; -.
DR TreeFam; TF313685; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030506; F:ankyrin binding; IEA:Ensembl.
DR GO; GO:0045214; P:sarcomere organization; IEA:Ensembl.
DR CDD; cd21310; CH_FLNC_rpt1; 1.
DR CDD; cd21314; CH_FLNC_rpt2; 1.
DR CDD; cd00173; SH2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 16..122
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 139..242
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 250..348
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 350..448
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 449..545
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 546..638
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 642..738
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 739..841
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 842..940
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 941..1036
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1037..1129
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1130..1224
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1225..1324
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1325..1417
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1418..1531
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1532..1628
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1629..1724
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1765..1834
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1834..1926
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1924..2013
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2016..2108
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2106..2205
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2208..2300
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2302..2395
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2399..2491
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2529..2623
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 969..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2624 AA; 279467 MW; 2ED2452F48E6BFEA CRC64;
MPSTEKDLAE DAPWKKIQQN TFTRWCNEHL KCVGKRLTDL QRDLSDGLRL IALLEVLSQK
RMYRKFHPRP NFRQMKLENV SVALEFLERE HIKLVSIDSK AIVDGNLKLI LGLIWTLILH
YSISMPMWED EDDEDARKQT PKQRLLGWIQ NKVPQLPITN FNRDWQDGKA LGALVDNCAP
GLCPDWEAWD PNQPVENARE AMQQADDWLG VPQVIAPEEI VDPNVDEHSV MTYLSQFPKA
KLKPGAPIRS KQLNPKKAIA YGPGIEPHGN TVLQPAHFTV QTVDAGVGEV LVYIEDPEGH
TEEAKVVPNN DKNRTYAVSY VPKVAGLHKV TVLFAGQNIE RSPFQVNVGM ALGDANKVSA
RGPGLEPVGN VANKPTYFDI YTAGAGTGDV AVVIVDPQGR RDTVEVALED KGDSTFRCTY
RPVMEGPHTV HVAFAGAPIT RSPFPVHVSE ACNPNACRAS GRGLQPKGVR VKEVADFKVF
TKGAGSGELK VTVKGPKGTE EPVKVQEAGD GVFECEYYPV VPGKYVVTIT WGGYAIPRSP
FEVQVSPEAG VQKVRAWGPG LETGQVGKSA DFVVEAIGTE VGTLGFSIEG PSQAKIECDD
KGDGSCDVRY WPTEPGEYAV HVICDDEDIR DSPFIAHIQP APPDCFPDRV KAFGPGLEPT
GCIVDKPAEF TIDARAAGKG DLKLYAQDAD GCPIDIKVIP NGDGTFRCSY VPTKPIKHTI
IISWGGVNVP KSPFRVNVGE GSHPERVKVY GPGVEKTGLK ANEPTYFTVD CSEAGQGDVS
IGIKCAPGVV GPAEADIDFD IIKNDNDTFT VKYTPPGAGR YTIMVLFANQ EIPASPFHIK
VDPSHDASKV KAEGPGLNRT GVEVGKPTHF TVLTKGAGKA KLDVQFAGAA KGEAVRDFEI
IDNHDYSYTV KYTAVQQGNM AVTVTYGGDP VPKSPFVVNV APPLDLSKVK VQGLNSKVAV
GQEQAFSVNT RGAGGQGHLD VRMTSPSRRP IPCKLEPGGG AEAQAVRYMP PEEGPYKVDI
TYDGHPVPGS PFAVEGVLPP DPTKVCAYGP GLKGGLVGSP APFSIDTKGA GTGGLGLTVE
GPCEAKIECQ DNGDGSCAVS YLPTEPGEYT INILFAEAHI PGSPFKATIR PVFDPSKVRA
SGPGLERGKA GEAATFTVDC SEAGDAELTI EILSDAGVKA EVLIQNNADG TYHITYSPAF
PGTYTITIKY GGHPVPKFPT RVHVQPAVDT SGVKVSGPGV EPHGVLREVT TEFTVDARSL
TATGGNHVTA RVLNPSGAKT DTYVTDNGDG TYRVQYTAYE EGMHLVEVLY DEVAVPKSPF
RVGVTEGCDP TRVRAFGPGL EGGLVNKSNR FTVETRGAGT GGLGLAIEGP SEAKMSCKDN
KDGSCTVEYI PFTPGDYDVN ITFGGRPIPG SPFRVPVKDV VDPGKVKCSG PGLGAGVRAR
VPQTFTVDCS QAGRAPLQVA VLGPTGTECL GQGGEGQAEC QGLCVAEPVE VRDNGGGTHT
VHYTPATDGP YTVAVKYADQ EVPRSPFKIK VLPAHDASKV RASGPGLNAS GIPASLPVEF
TIDARDAGEG LLTVQILDPE GKPKKANIRD NGDGTYTVSY LPDMSGRYTI TIKYGGDEIP
YSPFRIHALP TGDASKCLVT GACLGPRIQI GQETVITVDA KAAGEGKVTC TVSTPDGAEL
DVDVVENHDG TFDIYYTAPE PGKYVITIRF GGEHIPNSPF HVLLGGISSV EGIGVFLSDP
QTYYPWATEE PVVPVEPMES MLRPFNLVIP FAVQKGELTG EVRMPSGKTA RPNITDNKDG
TITVRYAPTE KGLHQMGIKY DGNHIPGSPL QFYVDAINSR HVSAYGPGLS HGMVNKPATF
TIVTKDAGEG GLSLAVEGPS KAEITCKDNK DGTCTVSYLP TAPGDYSIIV RFDDKHIPGS
PFTAKITGDD SMRTSQLNVG TSTDVSLKIT ESDLSQLTAS IRAPSGNEEP CLLKRLPNRH
IGISFTPKEV GEHVVSVRKS GKHVTNSPFK ILVGPSEIGD ASKVRVWGKG LSEGHTFQVA
EFIVDTRNAG YGGLGLSIEG PSKVDINCED MEDGTCKVTY CPTEPGTYII NIKFADKHVP
GSPFTVKVTG EGRMKESITR RRQAPSIATI GSTCDLNLKI PGEASSQDMT AQVTSPSGKM
EAAEIVEGED SAYSVRFVPQ EMGPHTVTVK YRGQHVPGSP FQFTVGPLGE GGAHKVRAGG
TGLERGVAGV PAEFSIWTRE AGAGGLSIAV EGPSKAEIAF EDRKDGSCGV SYVVQEPGDY
EVSIKFNDEH IPDSPFVVPV ASLSDDARRL TVTSLQETGL KVNQPASFAV QLNGARGVID
ARVHTPSGAV EECYVSELDS DKHTIRFIPH ENGVHSIDVK FNGAHIPGSP FKIRVGEQSQ
AGDPGLVSAY GPGLEGGTTG VSSEFIVNTL NAGSGALSVT IDGPSKVQLD CRECPEGHVV
TYTPMAPGNY LIAIKYGGPQ HIVGSPFKAK VTGPRLSGGH SLHETSTVLV ETVTKSSSSR
GSSYSSIPKF SSDASKVVTR GPGLSQAFVG QKNSFTVDCS KAGTNMMMVG VHGPKTPCEE
VYVKHMGNRV YNVTYTVKEK GDYILIVKWG DESVPGSPFK VNVP
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