ID   H0X1X7_OTOGA            Unreviewed;       575 AA.
AC   H0X1X7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Protein disulfide isomerase like, testis expressed {ECO:0000313|Ensembl:ENSOGAP00000009017.2};
GN   Name=PDILT {ECO:0000313|Ensembl:ENSOGAP00000009017.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000009017.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000009017.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC       {ECO:0000256|ARBA:ARBA00006347}.
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DR   EMBL; AAQR03077410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03077411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03077412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0X1X7; -.
DR   STRING; 30611.ENSOGAP00000009017; -.
DR   Ensembl; ENSOGAT00000010093.2; ENSOGAP00000009017.2; ENSOGAG00000010088.2.
DR   eggNOG; KOG0191; Eukaryota.
DR   GeneTree; ENSGT00940000160939; -.
DR   HOGENOM; CLU_025879_1_1_1; -.
DR   InParanoid; H0X1X7; -.
DR   OMA; APWSKKC; -.
DR   TreeFam; TF106381; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0003756; F:protein disulfide isomerase activity; IEA:Ensembl.
DR   GO; GO:0008354; P:germ cell migration; IEA:Ensembl.
DR   GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR   CDD; cd02961; PDI_a_family; 1.
DR   CDD; cd02995; PDI_a_PDI_a'_C; 1.
DR   CDD; cd02982; PDI_b'_family; 1.
DR   CDD; cd02981; PDI_b_family; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 4.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR18929; PROTEIN DISULFIDE ISOMERASE; 1.
DR   PANTHER; PTHR18929:SF58; PROTEIN DISULFIDE-ISOMERASE-LIKE PROTEIN OF THE TESTIS; 1.
DR   Pfam; PF00085; Thioredoxin; 2.
DR   Pfam; PF13848; Thioredoxin_6; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 4.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..575
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003545303"
FT   DOMAIN          369..492
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   REGION          520..575
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        539..554
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   575 AA;  66275 MW;  DA6D71D5648647B5 CRC64;
     MELLWMPLLL VGSCVVAVYS SVEDTSTPVN ITKPVHIVEE HNLLVLTPAG LTQMLNETRF
     LMVLFYNPSS KQSKNLAEEL GKAVEIMGKG KNGVGFGKVD ITVEKELKQE FNIKKTPELK
     LFFEGNRSEP ISCEGVVEST ALVVWLRRQI SQNAFLFNNS LQVANFVESR HLVIIGFFQD
     LEEEVAELFY DTIKDFPELT FGAIEIKNAA GHFHVVLDSV LVFKKGKLVN RQELINDDTN
     KQNLLQVIKQ HLTDFVLEYN TENKDLIYEL QILNHMLLFV SKSSESYGTI IQHYKLASKE
     FQNKILFILV DADEPRNRRV FEYFRITEVN VPSVQILNLT SDARYKMPSD EITFRNLKRF
     GLNFLSRNAK KHQSSEDIPK YWDQGLVKQL VGKNFNIVVF DKEKDVFVMF YAPWSENCRA
     LFPVLEQLGR MYQNHSTITI AKIDITANDI QLMYLERYPF FRLFPTDSQQ SVLYKGEYTL
     KGFSDFLENQ IKTRVEDELL FVEQNEVIEE EVLAEEEEIP MVEEELPKQQ LPKLENVTKP
     EEAAGKKEMA EEVVVVAKPK GPPGQEKKSK VKEEL
//