ID H0X313_OTOGA Unreviewed; 3406 AA.
AC H0X313;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=BRCA2 DNA repair associated {ECO:0000313|Ensembl:ENSOGAP00000009477.2};
GN Name=BRCA2 {ECO:0000313|Ensembl:ENSOGAP00000009477.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000009477.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000009477.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03137304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03137305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03137306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03137307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03137308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03137309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03137310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03137311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03137312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03137313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000009477; -.
DR Ensembl; ENSOGAT00000010591.2; ENSOGAP00000009477.2; ENSOGAG00000010588.2.
DR eggNOG; KOG4751; Eukaryota.
DR GeneTree; ENSGT00390000003602; -.
DR HOGENOM; CLU_000344_0_0_1; -.
DR InParanoid; H0X313; -.
DR OMA; CWYTKLG; -.
DR TreeFam; TF105041; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0033593; C:BRCA2-MAGE-D1 complex; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:1990391; C:DNA repair complex; IEA:Ensembl.
DR GO; GO:0000800; C:lateral element; IEA:Ensembl.
DR GO; GO:0000152; C:nuclear ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:Ensembl.
DR GO; GO:0010484; F:histone H3 acetyltransferase activity; IEA:Ensembl.
DR GO; GO:0010485; F:histone H4 acetyltransferase activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0071479; P:cellular response to ionizing radiation; IEA:Ensembl.
DR GO; GO:0090398; P:cellular senescence; IEA:Ensembl.
DR GO; GO:0051298; P:centrosome duplication; IEA:Ensembl.
DR GO; GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0070200; P:establishment of protein localization to telomere; IEA:Ensembl.
DR GO; GO:0008585; P:female gonad development; IEA:Ensembl.
DR GO; GO:0071425; P:hematopoietic stem cell proliferation; IEA:Ensembl.
DR GO; GO:0001833; P:inner cell mass cell proliferation; IEA:Ensembl.
DR GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
DR GO; GO:0007141; P:male meiosis I; IEA:Ensembl.
DR GO; GO:1990426; P:mitotic recombination-dependent replication fork processing; IEA:Ensembl.
DR GO; GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:Ensembl.
DR GO; GO:0001556; P:oocyte maturation; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0032465; P:regulation of cytokinesis; IEA:Ensembl.
DR GO; GO:0010332; P:response to gamma radiation; IEA:Ensembl.
DR GO; GO:0010225; P:response to UV-C; IEA:Ensembl.
DR GO; GO:0010165; P:response to X-ray; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0000722; P:telomere maintenance via recombination; IEA:Ensembl.
DR CDD; cd04493; BRCA2DBD_OB1; 1.
DR CDD; cd04494; BRCA2DBD_OB2; 1.
DR Gene3D; 6.10.70.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR048262; BRCA2_OB_2_dom.
DR InterPro; IPR015188; BRCA2_OB_3.
DR InterPro; IPR002093; BRCA2_repeat.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR015205; Tower_dom.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF09104; BRCA-2_OB3; 1.
DR Pfam; PF00634; BRCA2; 7.
DR Pfam; PF21318; BRCA2DBD_OB2; 1.
DR Pfam; PF09121; Tower; 1.
DR PIRSF; PIRSF002397; BRCA2; 1.
DR SMART; SM01341; Tower; 1.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS50138; BRCA2_REPEAT; 8.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 998..1032
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 1209..1243
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 1418..1452
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 1516..1550
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 1664..1698
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 1838..1872
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 1967..2001
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 2047..2081
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT DOMAIN 2820..2861
FT /note="Tower"
FT /evidence="ECO:0000259|SMART:SM01341"
FT REGION 357..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2414..2451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2430..2445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3406 AA; 383125 MW; AF636946851212A3 CRC64;
MSVGSKERPT FFEIFKTRCN EADLGPISLN WFEELSSEAT PFSSEPVEES EYKIISYESH
VFKTPQRKPF YRQLASTPLI FKEQGPTLPL FQSPVKELDK CKLDLGNNIA NSKHKSHHTG
NAKMDQAGDV TSPLLSSRLS ESPVLQYTHV TPQREKSVVC GSLFHTPKFV KGQTQKHISE
SLGAEVDPDM SWSSSLATPP TLSSTVLIVR SEDASEIVFP NDTTAILKSY FSNRDESLKE
NDRLISSVTD HENKNEREAR SCGLGKILGN SFDEVNSCKE YFGKSVPNIL EDKVRKAIAD
TSEEDSFSLC FKYKTRNLRK VRKDNTRKKV FHETKTGEYE EAKKQIKEKH SIISEMEPND
SDLLDSNEAK QKPFGNESDK ISKEIVESCA SEWSHLTLSG LSGTQMEKIS PLHISCNQNN
SEKDLVDTEK ECTDFITSEN SLPCISNIPK PEKILNEKTV VNKGGEPQHL ESYEDSILAV
KPAISGIPRT ASLFQDINKP IFKIRESSEE TSSAVFMGSM TDPNVKEETE TSESNLEIYT
ICSQKEDSLC PSSIDDESRL ATIAHTSVPL KNTGLISTLK KKTKKFIYAI NDETSYQGKK
IQKDQKSEIT NCSAQFESNV FQAPLSFTND NSGLLNSSVK RNCLQNDSEE PALSLTSSCG
TLLRKCCHNK SNSPNNPVIS QDFDYKEAKI NEEKLQPFIT SEMDYLSCQQ ERQCENDPKS
ENVSAIKEKV LATACYPVVH HSEVECSGMH IQSQKSLLYN HDNTSTLTLS SKDPWSESVV
ISSKKESYKM SEKERRKSCK VGFELTKNIF AEKNQEVCSL NENSKNAEPL LPENYITASP
SVKVQFNQNK NLSMIQKEET TLISKILDNP NSEELFQDNE NFVCQVTNGR NNLILGNSKE
LPEADLSCVK EPFLENSTMV VHADVGDRQA VQVLITKELD SSDTVYDFPE ENRNSVKQHL
KVTLDQDLKP DTSLVIDKKS NKNDCMDKQA GLLNPISNHN FGGGFRTASN KEIKFSEHNI
KKSKMLFKDI EEQYPASLIC VESINALELR NQKKLSKPHM LVSESINTVS SYVQSSPFVS
NSENNQTPPQ MLFSKQNFNS NHNLTPSQKA EITELSTILE ESGSQFEFTQ FRKPNLIMQS
NTFDVPANQM SLLNTTSEER KDVDLNVSSV GQVETSKKFE GAVQVKQKFT CLSENNCNKS
ASGYLTCENE VEFRGFYSAR GKKLNVSSEA LQKAVKLFGD IENISEETST EVDPRSFSSS
KCNDSIVSAF KIESHNNTNL NEKNNKCQLV LQNIEMTTDA FVDKSTENCK RNIIENDNKC
VAANRKTCNL GESDSSDSGK NDTIYIHKDA NDLPCTDQHN VYFKLPSQFV KEGNTQMKAS
LSDLTCLEIV KEEETCYVDT SNKEQLNASH MDQNRKDFEV FDISFQTASG KNIKVSKESL
NKVVNFFDPK TEEELNNFFL NSKLLSGISK NKVDILSHEE IDMFKNEILK ESISIDTQNQ
LSTLQQQPEC ENKKIKQATL LSFHTASGKK VKVAKESLEK VRNLFDEEKQ AISKISLNSQ
RAKIQKDRGE RTCKEGLVLA CKTVEITTVP KCEEMNSLGD NVENHVSNPT AVLPKPLSDH
FYRQSENIST PNVSLKVKVC ENVEKETAKS PATCYTNQSP YSAVENSALA FYTGHGRKIS
VSQASLFKAK KWLREELGDQ PEEINSDKNY VGNPSHGSGS NSIITENGKN HLPEKQDSAY
LSFSSMSNYS YHSDFYCSHD SGYLSKNTTD SSIEPVVKNI EDERNINFSE VTSTVREANA
YPQTVHKDTC IQKLVTNSSL CTNENTAFKL SVSNSDNFEV ETPAFSTASG KIVHVSRETI
KKVKEIFTDN CSKVIQMDTK SKSSTCQTRI VSDYYKTLDD SEDSLPNSTD EESSMHSHKI
FADIQNVHIL RDQSMLGLDK VSTLSPCDVS LKTSSLCNTG KFPELVSSTN PEIFSTASGK
SIQVSESSLQ QARQVFSEIE EHAKQHFSKV SFKNNEEYSD QFTREEKVIH VPQKLISQKG
FSCNVVNSPA FSGFSTASGK QVSVSESALH KVKGMLEEFD LIKTDCTLQH PPTSRPGISK
FPSLPCVDKR TAEYSMNSEM KKAYSTEFKL LNNFNIESNT SENNHSIKVP PYMSQFKQDK
QQLVLGTKVS LVENIHILGK EQALPKNIKM GIGKTETFPD VPMKTNIEVS STYYKDSENY
FETEAVEIAK AFMEDGELTD SEPLSHAEHT RFTCQENEET VWLNSRIGKR RGDNHVSFGE
PSIKRNLLNE FDRILENQEK SLKVSKSTPD GTMKDRRLFM QHVYLEPITC GPFCTTKKRQ
GIQNPNFTAP GQEFLSKSHF YEHLTSENSS SNLSVLGQPF YKVPATRSKE MRHSISTGKS
TKIFVPPFKT KSHFHRDKQC ASNTVVEENK QKQNTDEHDS GDSENNNSEI HQLNKNNSNQ
ACEEEPLDLI TSLQNARDTQ DMRIKKKQRH HISPQPGSLY LAKTSSLPRI SLKAAVGGRV
PSACSHKQLY MYGVSKHCIK INSKNAESFQ FHIQDYFGKE YLWAGKGIQL ADGGWLIPSN
DGKAGKEEFY RALCDTPGVD PKLISRVWVY NHYRWIIWKL AAMEFAFPKE FANRCLSPER
VLLQLKYRYD LEIDRSRRSA LKKIMEKDDT AAKTLVLCVS DIISLSANIC ETSNSKTNSE
DTKKVSVIEL TDGWYAVKAL LDPPLLALLK NGRLSVGQKI IIHGAELLGS PEACTPLEAP
QSLMLKISAN STRPARWYTK LGFFPDPRPF PLRLSSLFSD GGNVGCADII IQRTYPIQWM
EKTSSGLYIF RNEREEEKEA AKYAEAQQKR LEALFTKIQA EFEEREDNNN NNFLPFSNVA
TWTVPVRRYR DVCFLFQYVK WSQCYFSEEQ LRALNNHRQM LNDKKQAQIQ LEFRKAMESA
EQGEQGLSRD VTTVWKLRII SCAKEETDSV TLSIWCPSTE LYSLLTEGKR YRIYHLAASK
SKIKSEKANI QLAATKKTQY QELPASDEIL FQVYQPREPL HFNRLLDPDF QPPCCEVDLI
GVVVSVVKKT VLGLAPLVYL SDECHNLLAI KFWIDLNEDI IKLHALIAAS NLLWRPESKS
GIPTLFAGDF SMFSASPKES HFQETFNKMR NTIENIDIFC KDAENKLIHM LNASDPKWCT
PTKDSTSELH TAQTVLGTGN KFLISSPNSE INYQSPSSLC TPKVKLVSTP ISAQMTSKSC
CKGEKAIDDP KSCKKRRALD FLSRLPLPPP VSPICTFVSP AAQKAFQPPR SIVTKYETPI
KKKELNSPQM PSPKKFIEIS PLESNLIADE ELALINTQAL LSSSAGEDQC VSISEPPGTT
TTNSKDYLRL KRHCTTSLNK EPKNPQVSTE DCATNMQDTS IIKDIS
//
