ID H0X3P9_OTOGA Unreviewed; 720 AA.
AC H0X3P9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Hook microtubule tethering protein 3 {ECO:0000313|Ensembl:ENSOGAP00000009770.2};
GN Name=HOOK3 {ECO:0000313|Ensembl:ENSOGAP00000009770.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000009770.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000009770.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the hook family.
CC {ECO:0000256|ARBA:ARBA00006946}.
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DR EMBL; AAQR03106062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03106063; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03106064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03106065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03106066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03106067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03106068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X3P9; -.
DR STRING; 30611.ENSOGAP00000009770; -.
DR Ensembl; ENSOGAT00000010917.2; ENSOGAP00000009770.2; ENSOGAG00000010911.2.
DR eggNOG; ENOG502QQM8; Eukaryota.
DR GeneTree; ENSGT00940000158075; -.
DR HOGENOM; CLU_011214_1_0_1; -.
DR InParanoid; H0X3P9; -.
DR OMA; DAKYRKC; -.
DR OrthoDB; 50921at2759; -.
DR TreeFam; TF320231; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005801; C:cis-Golgi network; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0070695; C:FHF complex; IEA:Ensembl.
DR GO; GO:0030897; C:HOPS complex; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000242; C:pericentriolar material; IEA:Ensembl.
DR GO; GO:0034452; F:dynactin binding; IEA:Ensembl.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:Ensembl.
DR GO; GO:0045503; F:dynein light chain binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:Ensembl.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR GO; GO:0045022; P:early endosome to late endosome transport; IEA:Ensembl.
DR GO; GO:0007032; P:endosome organization; IEA:Ensembl.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0051645; P:Golgi localization; IEA:Ensembl.
DR GO; GO:0022027; P:interkinetic nuclear migration; IEA:Ensembl.
DR GO; GO:0007040; P:lysosome organization; IEA:Ensembl.
DR GO; GO:0034454; P:microtubule anchoring at centrosome; IEA:Ensembl.
DR GO; GO:0050768; P:negative regulation of neurogenesis; IEA:Ensembl.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0071539; P:protein localization to centrosome; IEA:Ensembl.
DR GO; GO:1905719; P:protein localization to perinuclear region of cytoplasm; IEA:Ensembl.
DR CDD; cd22226; HkD_Hook3; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR008636; Hook_C.
DR InterPro; IPR043936; HOOK_N.
DR PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR PANTHER; PTHR18947:SF38; PROTEIN HOOK HOMOLOG 3; 1.
DR Pfam; PF05622; HOOK; 1.
DR Pfam; PF19047; HOOK_N; 1.
DR SUPFAM; SSF116907; Hook domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 10..126
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 684..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 171..430
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 489..652
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 688..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 83315 MW; B3705600C7E70281 CRC64;
MFNVESVERV ELCESLLTWI QTFNVDAPCQ TVEDLTNGVV MAQVLQKIDP AYFDENWLNR
IKTEVGDNWR LKISNLKKIL KGILDYNHEV LGQQINDFTL PDVNLIGEHS DAAELGRMLQ
LILGCAVNCE QKQEYIQAIM MMEESVQHVV MTAIQELMSK ESPVSAGNDA YVDLDRQLKK
TTEELNEALS AKEEIAQRCH ELDMQVAALQ EEKSSLLAEN QILMERLNQS DSIEDPNSPA
GRRHLQLQTQ LEQLQEETFR LEAAKDDYRI RCEELEKEIS ELRQQNDELT TLADDAQSLK
DEIDVLRHSS DKVSKLEGQV ESYKKKLEDL GDLRRQVKLL EEKNSVYMQN TVSLEEELRK
ANAARSQLET YKRQVVELQN RLSEESKKAD KLDFEYKRLK EKVDSLQKEK DRLRTERDSL
KETIEELRCV QAQEGQLTTQ GLMPLGSQES SDSLAAEIVT PEIREKLIRL QHENKMLKLN
QEGSDNEKIA LLQSLLDDAN LRKNELETEN RLVNQRLLEV QSQVEELQKS LQDQGSKAED
AISVLLKKKL EEHLEKLHEA NNELQKKRAI LEDLEPRFTH SSLKIEELQE ALRKKEEEMK
QMEERYKKYL EKAKSVIRTL DPKQNQGAAP EIQALKNQLQ ERDRLFHSLE KEYEKTKSQR
EMEEKYIVSA WYNMGMTLHK KAAEDRLAST GSGQSFLARQ RQATSTRRSY PGHVQPATAR
//
