ID H0X3S4_OTOGA Unreviewed; 486 AA.
AC H0X3S4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN Name=HEXD {ECO:0000313|Ensembl:ENSOGAP00000009799.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000009799.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000009799.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
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DR EMBL; AAQR03040780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003786088.1; XM_003786040.2.
DR AlphaFoldDB; H0X3S4; -.
DR STRING; 30611.ENSOGAP00000009799; -.
DR Ensembl; ENSOGAT00000010951.2; ENSOGAP00000009799.2; ENSOGAG00000010947.2.
DR eggNOG; ENOG502QRCP; Eukaryota.
DR GeneTree; ENSGT00390000014852; -.
DR HOGENOM; CLU_019666_1_1_1; -.
DR InParanoid; H0X3S4; -.
DR OMA; WEVYDEH; -.
DR OrthoDB; 2876932at2759; -.
DR TreeFam; TF314313; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:1903561; C:extracellular vesicle; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06565; GH20_GcnA-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR038901; HEXDC-like.
DR PANTHER; PTHR21040:SF6; HEXOSAMINIDASE D; 1.
DR PANTHER; PTHR21040; UNCHARACTERIZED; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 61..205
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
SQ SEQUENCE 486 AA; 54213 MW; DC46CFD3FB035E9C CRC64;
MSDSTPFAMR LVHLDLKGAP PKVSYLSKVF PLFRALGANG LLVEYEDMFP YEGPLRLLRA
KHAYSPSEIK EILRLARMNE LEVVPLVQTF GHMEFVLKHL AFAHLREVAS FPNTLNPHEA
ESLALVGAMI DQVLEQHPGT RRLHIGCDEV YYLGEGEASR QWLQQEQNSK VKLCLSHIRA
VASHVLTWHP CTTPLVWDDM LRDMPQDQLT ASGVPELVEP VLWDYAADLD VHGKVLLMHK
YQECGFQRLW AASAYKGATG PSQALPPVEH HLRNHECWLQ VAGGGPAGLL QGIVLTGWQR
HDHFSVLCEL LPVGVPSLAA CLQLLLHGGF SEDVKSRVEN ILGVSSVETA SPVSEGASSF
PGSDILSLVT HFSLHLRSSV DALLERNRYV TGWFGPYHRR RKLIHPVMVQ HIQPEALSLL
ARWSPLVREL EAALHQAFYP DAVEEWLEEN VLPSVQRLQV LLQDLSEAAA NTNPPAGPSW
DTCQDP
//
