ID H0X3T5_OTOGA Unreviewed; 813 AA.
AC H0X3T5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Active breakpoint cluster region-related protein {ECO:0000256|ARBA:ARBA00019427};
GN Name=ABR {ECO:0000313|Ensembl:ENSOGAP00000009813.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000009813.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000009813.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR EMBL; AAQR03159652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03159653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03159654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03159655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03159656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03159657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03159658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03159659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03159660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03159661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X3T5; -.
DR STRING; 30611.ENSOGAP00000009813; -.
DR Ensembl; ENSOGAT00000010965.2; ENSOGAP00000009813.2; ENSOGAG00000010957.2.
DR eggNOG; KOG4269; Eukaryota.
DR GeneTree; ENSGT00940000153491; -.
DR HOGENOM; CLU_004000_1_0_1; -.
DR InParanoid; H0X3T5; -.
DR OMA; TMFYKIP; -.
DR TreeFam; TF105082; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd08686; C2_ABR; 1.
DR CDD; cd13366; PH_ABR; 1.
DR CDD; cd04387; RhoGAP_Bcr; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR037865; ABR_PH.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182:SF5; ACTIVE BREAKPOINT CLUSTER REGION-RELATED PROTEIN; 1.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 45..238
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 255..413
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 438..567
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 601..799
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 813 AA; 92485 MW; 293986A1EA3459D9 CRC64;
MPYIDESPTM SPQLSARSQG GGDSISPTPP EGLAPGVDAG KGLEMRKLVL SGFLASEEIY
INQLEALLLP MKPLKATATT SQPVLTIQQI ETIFYKIQDI YEIHKEFYDN LCPKVQQWDS
QVTMGHLFQK LASQLGVYKA FVDNYKVALE TAEKCSQSNN QFQKISEELK VKGPKDSKDS
HTSVTMEALL YKPIDRVTRS TLVLHDLLKH TPVDHPDYPL LQDALRISQN FLSSINEDID
PRRTAVTTPK GETRQLVKDG FLVEVSESSR KLRHVFLFTD VLLCAKLKKT SAGKHQQYDC
KWYIPLADLV FPSPEESEAS PQVHPFPDHE LEDMKMKISA LKSEIQKEKA NKGQSRAIER
LKKKMFENEF LLLLNSPTIP FRIHNRNGKS YLFLLSSDYE RSEWREAIQK LQKKDLQAFV
LSSVELQVLT GSCFKLRTVH NIPVTSNKDD DESPGLYGFL HVIVHSAKGF KQSANLYCTL
EVDSFGYFVS KAKTRVFRDT TEPKWDEEFE IELEGSQSLR ILCYEKCYDK TKVNKDNNEI
VDKIMGKGQI QLDPQTVETK NWHTDVIEMN GIKVEFSMKF TSRDMSLKRT PSKKQTGVFG
VKISVVTKRE RSKVPYIVRQ CVEEVEKRGI EEVGIYRISG VATDIQALKA VFDANNKDIL
LMLSDMDINA IAGTLKLYFR ELPEPLLTDR LYPAFMEGIA LSDPAAKENC MMHLLRSLPD
PNLITFLFLL EHLKRVAEKE PINKMSLHNL ATVFGPTLLR PSEVESKAHL TSAADIWSHD
VMAQVQVLLY YLQHPPISFA ELKRNTLYFS TDV
//
