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Database: UniProt
Entry: H0X446_OTOGA
LinkDB: H0X446_OTOGA
Original site: H0X446_OTOGA 
ID   H0X446_OTOGA            Unreviewed;       442 AA.
AC   H0X446;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-OCT-2019, entry version 44.
DE   SubName: Full=ETS variant 6 {ECO:0000313|Ensembl:ENSOGAP00000009945};
GN   Name=ETV6 {ECO:0000313|Ensembl:ENSOGAP00000009945};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000009945, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000009945}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000009945}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; AAQR03139068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03139069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03139070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03139071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03139072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03139073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03139074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03139075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03139076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000009945; -.
DR   Ensembl; ENSOGAT00000011116; ENSOGAP00000009945; ENSOGAG00000011110.
DR   eggNOG; KOG3804; Eukaryota.
DR   eggNOG; ENOG4111K4J; LUCA.
DR   GeneTree; ENSGT00940000159508; -.
DR   InParanoid; H0X446; -.
DR   OMA; IENNHCP; -.
DR   TreeFam; TF318679; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0071425; P:hematopoietic stem cell proliferation; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT   DOMAIN       30    114       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      329    410       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION        1     21       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      145    251       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    215    235       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   442 AA;  52061 MW;  03E11AB91C59ED75 CRC64;
     QQERISYTPP ESPVTSYASS TPLHVPVPRA LRMEEDSIRL PAHLRLQPIY WSRDDVAQWL
     KWAENEFSLR PIDSNTFEMN GKALLLLTKE DFRYRSPHSG DVLYELLQHI LKQRKPRILF
     SPFFHPGNSI HTQPEVILHQ NHEEENCVQR TPRPSVENVH HNPPTIELLH RSRSPITANH
     RPSPDPEQRP LRSPLDNMIR RLSPAERAQG PRLHQENNHQ EPYPLSVSPM ENNHCPPSSE
     PHPKPSSPRQ ENTRVIQLMP SPIMHPLILN PRHSMDFKQS RLSEDGLHRE GKPINLSHRE
     DMAYVNHIMV SVSPPEEHAM PIGRIADCRL LWDYVYQLLS DSRYENFIRW EDKESKIFRI
     VDPNGLARLW GNHKNRTNMT YEKMSRALRH YYKLNIIRKE PGQRLLFRFM KTPDEIMSGR
     TDRLEHLESQ ELDEQIYQED EC
//
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