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Database: UniProt
Entry: H0X4C4_OTOGA
LinkDB: H0X4C4_OTOGA
Original site: H0X4C4_OTOGA 
ID   H0X4C4_OTOGA            Unreviewed;      1719 AA.
AC   H0X4C4;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   08-MAY-2019, entry version 55.
DE   SubName: Full=Laminin subunit alpha 4 {ECO:0000313|Ensembl:ENSOGAP00000010038};
GN   Name=LAMA4 {ECO:0000313|Ensembl:ENSOGAP00000010038};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000010038, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000010038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000010038}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AAQR03003965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03003966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03003967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03003968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03003969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03003970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03003971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03003972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000010038; -.
DR   Ensembl; ENSOGAT00000011214; ENSOGAP00000010038; ENSOGAG00000011205.
DR   eggNOG; ENOG410KCXD; Eukaryota.
DR   eggNOG; ENOG410Z3D5; LUCA.
DR   GeneTree; ENSGT00940000159970; -.
DR   InParanoid; H0X4C4; -.
DR   OMA; GMDCPTI; -.
DR   TreeFam; TF335359; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR   GO; GO:0043083; C:synaptic cleft; IEA:Ensembl.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR   GO; GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IEA:Ensembl.
DR   GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR   GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR   GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR009254; Laminin_aI.
DR   InterPro; IPR010307; Laminin_dom_II.
DR   InterPro; IPR002049; Laminin_EGF.
DR   InterPro; IPR001791; Laminin_G.
DR   Pfam; PF00053; Laminin_EGF; 3.
DR   Pfam; PF02210; Laminin_G_2; 5.
DR   Pfam; PF06008; Laminin_I; 1.
DR   Pfam; PF06009; Laminin_II; 1.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00180; EGF_Lam; 3.
DR   SMART; SM00282; LamG; 5.
DR   SUPFAM; SSF49899; SSF49899; 5.
DR   PROSITE; PS01248; EGF_LAM_1; 1.
DR   PROSITE; PS50027; EGF_LAM_2; 3.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00814887};
KW   Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00580772};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Repeat {ECO:0000256|SAAS:SAAS00814929}.
FT   DOMAIN        1     32       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN       33     87       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN       88    141       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      734    936       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN      948   1128       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     1135   1303       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     1365   1536       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     1543   1716       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   COILED      240    267       {ECO:0000256|SAM:Coils}.
FT   COILED      282    302       {ECO:0000256|SAM:Coils}.
FT   COILED      379    406       {ECO:0000256|SAM:Coils}.
FT   COILED      488    515       {ECO:0000256|SAM:Coils}.
FT   COILED      570    590       {ECO:0000256|SAM:Coils}.
FT   COILED      603    626       {ECO:0000256|SAM:Coils}.
FT   DISULFID      2     11       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID     58     67       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    113    122       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    125    139       {ECO:0000256|PROSITE-ProRule:PRU00460}.
SQ   SEQUENCE   1719 AA;  191405 MW;  1620F46A7E4A2677 CRC64;
     HCQRNTTGEH CERCLDGYIG DSIRGTPRFC QPCPCPLPHL ANFAESCYRK NGAVRCMCKE
     NYAGPNCERC APGYYGNPLL IGSTCKKCDC SGNSDPNLIF EDCDEVTGQC RNCLRNTTGF
     KCERCAPGYY GDARIAKNCA VCNCGGGPCD SVTGECLEEG FEPPTGMDCP TISCDKCVWD
     LTDDLRLAAL SIEESKSGLL SVSSGAASHR HVNEINATIY LLKTKLSERE NQYVLRKIQI
     NNAENTMKSL LSDVEELAEK ESQASRKGQL AQKESLDTIN HATQLVQQAH DMRDKIQEIN
     NKMLYYGEEQ ELSPEEIAEK LVLAQQMLEE IRHKPPFLAQ QELVDEEADE AYELLSQAES
     WQRLHNDTRA LFPVVLEQLD DYNAKLSDLQ ESLDQALDRV RDAEDMNRAT AARQRDHEKQ
     HERVREQMEV VNTSLRASAH SLTMPRLTLS ELDDVIKNAS GIYAGIDGAT NELQVKLSNL
     SNLSHDLVQE ATDHAQNLQQ EADELIRKLH SSDMNGLVQK ALDASNVYEN IVNYVSEANE
     TAEFTLNITD RIYDAVSGID TQIIYHKDES ENLLNQAREL QARADSSNEE AVADTSRRVG
     GALARKSALK NRLNDAVKQL QAAERGDAQQ RLGQSQLITA EVNKTTMEVQ RATAPMANNL
     TTWSQNLQRF DSSAYNTAVD SARDAVRNLT EVVPQLLDQL RVVELKRPAS NVSASIQRIR
     ELIAQTRSVA SKIQVSMMFD GQSAVEVHPK TSVDDLKAFT SLSLYMKPPV KSPELAGPAD
     QFVLYLGSKN AKKEYMGLAI KNDNLVYIYN LGAKDVEIPL DSKPVSSWPA HFSIVKIERI
     GKHGKVFLTV PSLSSTAEEK FIKKGEFAGD DSLLDLDPED TVFYVGGVPS NFKLPAPLDL
     PGFVGCLELA TLNNDVISLY NFKHIYNMDP STSVPCARDK LAFTQSRAAS YFFDGSSYAV
     VRDITRRGKF GQVTRFDIEV RTPADNGLIL LMVNGSMFFR LEMRSGYLHV LYDFGFSNGP
     VHLEDTLKKA QINDAKYHEI SIIYHNDKKM ILVVDRRHIK SMDNEKMKIP FTDIYIGGAP
     PEILQSRTLR THLPLDINFR GCMKGFQFQK KDFNLLEQTE TLGVGYGCPE DSLISRRVYF
     NGQSFIASVQ KISFFDGFEG GFNFRTLQPS GLLFYYASGS DVFSISLDNG TVIMDVKGVK
     VQSAEKQYND GLSHFIITSV SPTRYELMVD KSKHVNKNPA KGKAEQTQAG EKKFYFGGSP
     VRTQYANFTG CISNAYFTRL DRDVEVEDFQ RYSEKVHTSL YECPIESSPL FLLHKKGKNF
     SKPKPSQNKK VRDNAAPAPV ALMLHALDTA ALQIYSSFPR AIEHAYQYGG TANSRQEFEH
     LKGDFGEKSQ FSIRLKTRSS HGMIFYVSDQ EENDFMTLFL AHGRLVFMFN VGHKKLKIRS
     QEKYNDGSWH DVIFIREKSS GRLVIDGLRV LEESLPPTAA TWKIKGPIYL GGVAPGRAVK
     NVQINSVYSF SGCLSNLQLN GASITSASQT FSVTPCFEGP METGTYFSTE GGYVVLDESF
     NIGLKFEIAF EVRPRSSSGT LVHGHSVNGE YLNVHMKNGQ VIVKVNNGIR DFSTSVTPKQ
     SLCDGRWHRI TVIRDSNVVQ LDVDSEVNHV VGPLNPKPVD HREPVFVGGV PESLLTPRLA
     PSKPFTGCIR HFVIDGRPVS FSKAALVSGA VSINSCPAA
//
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