ID H0X4G0_OTOGA Unreviewed; 292 AA.
AC H0X4G0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Inflammation and lipid regulator with UBA-like and NBR1-like domains {ECO:0000313|Ensembl:ENSOGAP00000010083.2};
GN Name=ILRUN {ECO:0000313|Ensembl:ENSOGAP00000010083.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000010083.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000010083.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03060439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03060440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03060441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03060442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03060443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03060444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03060445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03060446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03060447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03060448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X4G0; -.
DR STRING; 30611.ENSOGAP00000010083; -.
DR Ensembl; ENSOGAT00000011266.2; ENSOGAP00000010083.2; ENSOGAG00000011264.2.
DR eggNOG; KOG4351; Eukaryota.
DR GeneTree; ENSGT00490000043415; -.
DR HOGENOM; CLU_076188_1_0_1; -.
DR InParanoid; H0X4G0; -.
DR OMA; ESKWRMS; -.
DR TreeFam; TF105872; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0050687; P:negative regulation of defense response to virus; IEA:Ensembl.
DR GO; GO:1900181; P:negative regulation of protein localization to nucleus; IEA:Ensembl.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0032480; P:negative regulation of type I interferon production; IEA:Ensembl.
DR CDD; cd14947; NBR1_like; 1.
DR CDD; cd14349; UBA_CF106; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR039517; C6orf106_UBA-like.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032350; N_BRCA1_central.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR20930; OVARIAN CARCINOMA ANTIGEN CA125-RELATED; 1.
DR PANTHER; PTHR20930:SF0; PROTEIN ILRUN; 1.
DR Pfam; PF16158; N_BRCA1_IG; 1.
DR Pfam; PF14555; UBA_4; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 82..179
FT /note="Next to BRCA1 central"
FT /evidence="ECO:0000259|Pfam:PF16158"
FT REGION 199..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 292 AA; 32324 MW; F9386B4D0D8F269E CRC64;
MEGMDVDLDP ELMQKFSCLG TTDKDVLISE FQRLLGFQLN PAGCAFFLDM TNWNLQAAIG
AYYDFESPNI SVPSMSFVED VTIGEGESIP PDTQFIKTWR IQNSGAEAWP PGVCLKYVGG
DQFGHVNMVM VRSLEPQEIA DVSVQMCSPS RAGMYQGQWR MCTATGLYYG DVIWVILSVE
VGGLLGVTQQ LSSFETEFNT QPHRKVEGNF NPFASPQKNR QSDENNLKDP GGSEFDSISK
NTWAPAPDQT EQDQNRLSQN SVNLSPSSHA NNLSVVTYSK QSNTKAYPFS PP
//
