ID H0X4X5_OTOGA Unreviewed; 266 AA.
AC H0X4X5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=AlkB homolog 6 {ECO:0000313|Ensembl:ENSOGAP00000010289.2};
GN Name=ALKBH6 {ECO:0000313|Ensembl:ENSOGAP00000010289.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000010289.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000010289.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the alkB family.
CC {ECO:0000256|ARBA:ARBA00007879}.
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DR EMBL; AAQR03125263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X4X5; -.
DR STRING; 30611.ENSOGAP00000010289; -.
DR Ensembl; ENSOGAT00000011493.2; ENSOGAP00000010289.2; ENSOGAG00000011490.2.
DR eggNOG; KOG3200; Eukaryota.
DR GeneTree; ENSGT00510000048626; -.
DR HOGENOM; CLU_059836_2_0_1; -.
DR InParanoid; H0X4X5; -.
DR OMA; ILQDEMY; -.
DR TreeFam; TF314467; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR032862; ALKBH6.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR PANTHER; PTHR46030; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6; 1.
DR PANTHER; PTHR46030:SF1; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6; 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 124..255
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT REGION 167..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 266 AA; 29467 MW; ECFD1B2D4EC6A0A1 CRC64;
VAGGGMEVLN LEIGGDTGLR TGYKELVSME EQDSRVPALE PFRVEQAPPV IYYVPDFISK
EEEEYLLRQV FNAPKPKWTQ LSGRRLQNWG GLPHPRGMVP ERLPPWLQRY VDKVSDLRLF
GGLPANHVLV NQYLPGEGIM PHEDGPLYYP TVSTISLGSH TILDLYEPRQ PEDDDPMEQP
RPPPQPTTSL LLEPRSLLVL RGTAYTRLLH GIAATSIDAL DSTSLPSNAA ACPLARPGAC
LVRGTRVSLT IRRVPRVLRA GLLLSK
//
