ID H0X508_OTOGA Unreviewed; 847 AA.
AC H0X508;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Ras and Rab interactor 2 {ECO:0000313|Ensembl:ENSOGAP00000010328.2};
GN Name=RIN2 {ECO:0000313|Ensembl:ENSOGAP00000010328.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000010328.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000010328.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RIN (Ras interaction/interference) family.
CC {ECO:0000256|ARBA:ARBA00006919}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03145471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03145472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03145473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03145474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03145475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03145476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03145477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03145478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03145479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03145480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X508; -.
DR STRING; 30611.ENSOGAP00000010328; -.
DR Ensembl; ENSOGAT00000011542.2; ENSOGAP00000010328.2; ENSOGAG00000011531.2.
DR eggNOG; KOG2320; Eukaryota.
DR GeneTree; ENSGT00940000154866; -.
DR HOGENOM; CLU_011829_1_0_1; -.
DR InParanoid; H0X508; -.
DR OMA; CISRKIR; -.
DR TreeFam; TF331067; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
DR GO; GO:1904906; P:positive regulation of endothelial cell-matrix adhesion via fibronectin; IEA:Ensembl.
DR GO; GO:2001214; P:positive regulation of vasculogenesis; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd16131; RA_Rin2; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23101:SF51; RAS AND RAB INTERACTOR 2; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 52..148
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 570..709
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT DOMAIN 739..830
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 242..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..276
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 94460 MW; 56420CBA960D2AA8 CRC64;
MAWNPSKPTV VRHDSGCSEE EDVKICPRDS GYDSLSNRLS VLDRLLHTHP IWLQLGLSEE
EVAEVLQPQP PGLFLVHKST KMQKKVLSLR LPQECGTSLK EFAIKESAYT FSLEGSGISF
ADLFRLIAFY CISRKIRDVL PFTLKLPYAI STAKTEAKLE ELAQLGLNFW SSPADTKPPN
SPAPHSPLSS DGVCPASLRQ LCLINGVHSI KTRTPSELEC SQTNGALCFI NPLFLKVHSQ
DLSGGLKRPS TRTPNANGTE RPRSPPPRPP PPAINSLHTS PRLSGTETQT SVPETVNHNK
HGNVALPGTK PTPIPPPRLK KQASFLEAEG GAKTLTGGRP GAGAAGSAGG APPAAAPGDC
TRAPPPGVES RPPRHGGRQR LSDLSISTSS SDSLEYDRSM PLFGYEADTN SSLDDYEGES
DQETMAPPVK SKKKRSSSFV LPKLVKSQLQ KVSGVFSSFM TPEKRMVRRI AELSRDKCTY
FGCLVQDYVS FLQENRDCHV SSTDLLQTIR QFMTQVKNYL SQSSELDPPI ESLIPEDQID
VVLEKAMHKC ILKPLKGHVE AMLKDFHVAD GSWKQLKDNL QLVRQRNPQE LGVFAPTPDF
VDVEKIKVKF MTMQKMYSPE KKVMLLLRVC KLIYTVMENN SGRMYGADDF LPVLTYVIAQ
CDMLELDTEV EYMMELLDPS LLHGEGGYYL TSAYGALSLI KNFQEEQAAR LLSSETRDTL
RQWHKRRTAN RTIPSVDDFQ NYLRVAFQEV GSGCTGKTLL VRPYVTTEDV CQICAEKFKV
QDPEEYSLFL FVDETWQQLA EDTYPQKIKA ELHSRPQPHI FHFVYKRVKS DSYGVIFQNE
DEDLTTS
//
