ID H0X577_OTOGA Unreviewed; 705 AA.
AC H0X577;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Aryl hydrocarbon receptor nuclear translocator 2 {ECO:0000313|Ensembl:ENSOGAP00000010415.2};
GN Name=ARNT2 {ECO:0000313|Ensembl:ENSOGAP00000010415.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000010415.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000010415.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03026770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03026771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03026772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03026773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X577; -.
DR STRING; 30611.ENSOGAP00000010415; -.
DR Ensembl; ENSOGAT00000011641.2; ENSOGAP00000010415.2; ENSOGAG00000011634.2.
DR eggNOG; KOG3561; Eukaryota.
DR GeneTree; ENSGT00940000158198; -.
DR HOGENOM; CLU_011864_1_1_1; -.
DR InParanoid; H0X577; -.
DR OMA; RVRKDCY; -.
DR TreeFam; TF319983; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0017162; F:aryl hydrocarbon receptor binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR CDD; cd18947; bHLH-PAS_ARNT; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR23042:SF6; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR 2; 1.
DR PANTHER; PTHR23042; CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 14..67
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 85..160
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 293..344
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 77947 MW; B45818AE9A554ADA CRC64;
MDFDDEDGEG PSKFSRENHS EIERRRRNKM TQYITELSDM VPTCSALARK PDKLTILRMA
VSHMKSMRGT GNKSTDGAYK PSFLTEQELK HLILEAADGF LFVVAAETGR VIYVSDSVTP
VLNQPQSEWF GSTLYEQVHP DDVEKLREQL CTSENSMTGR ILDLKTGTVK KEGQQSSMRM
CMGSRRSFIC RMRCGNAPLD HLPLSRITTM RKRFRNGLGP VKEGEAQYAV VHCTGYIKAW
PPAGMTIPEE DADVGQGSKY CLVAIGRLQV TSSPVCMDMN GMSVPTEFLS RHNSDGIITF
VDPRCISVIG YQPQDLLGKD ILEFCHPEDQ SHLRESFQQV VKLKGQVLSV MYRFRTKNRE
WMLIRTSSFT FQNPYSDEIE YIICTNTNVN SRCQDFLPSI RGAVWRSQAW PLSQEPLEYV
AGALARQLQQ QQAELEVHQR DGLSSYDLSQ VPVPNLPGGV HESGKSVEKT DAIFSQERDP
RFAEMFAGIS ASEKKMMSSA SAAGSQQIYS QGSPFPPGHS GKAFSSSVVH VPGVNDIQSS
SSTGQNMSQI SRQLNQSQVS WTGSRPPFPG QQIPSQSSKT QSSPFGIGTS HSYPADPSSY
SPLSSPATSS PSGNAYSSLA NRTPGFAAES GQGSGQFQGR PSEVWSQWQS QHHGQQSGEQ
HSHQQPGQTE VFQDMLPMPG DPTQGTGNYN IEDFADLGMF PPFSE
//
