ID H0X5G3_OTOGA Unreviewed; 780 AA.
AC H0X5G3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 21 {ECO:0000256|ARBA:ARBA00020102};
DE AltName: Full=Coiled-coil domain-containing protein 128 {ECO:0000256|ARBA:ARBA00031617};
DE AltName: Full=KLRAQ motif-containing protein 1 {ECO:0000256|ARBA:ARBA00031361};
GN Name=PPP1R21 {ECO:0000313|Ensembl:ENSOGAP00000010516.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000010516.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000010516.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC Endosome {ECO:0000256|ARBA:ARBA00004177}.
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DR EMBL; AAQR03051712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03051713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03051714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03051715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03051716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03051717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03051718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03051719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03051720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03051721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003787951.1; XM_003787903.2.
DR AlphaFoldDB; H0X5G3; -.
DR STRING; 30611.ENSOGAP00000010516; -.
DR Ensembl; ENSOGAT00000011754.2; ENSOGAP00000010516.2; ENSOGAG00000011747.2.
DR GeneID; 100949653; -.
DR KEGG; oga:100949653; -.
DR CTD; 129285; -.
DR eggNOG; KOG4421; Eukaryota.
DR GeneTree; ENSGT00390000006820; -.
DR HOGENOM; CLU_022372_0_0_1; -.
DR InParanoid; H0X5G3; -.
DR OMA; NLHTYTE; -.
DR OrthoDB; 2882462at2759; -.
DR TreeFam; TF320535; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR InterPro; IPR040024; PPP1R21.
DR InterPro; IPR049372; PPP1R21_C.
DR InterPro; IPR019343; PPP1R21_N.
DR InterPro; IPR019348; PPP1R21_six_helix.
DR PANTHER; PTHR21448:SF0; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21; 1.
DR PANTHER; PTHR21448; SMOOTH MUSCLE MYOSIN HEAVY CHAIN-RELATED; 1.
DR Pfam; PF10205; KLRAQ; 1.
DR Pfam; PF21636; PPP1R21_C; 1.
DR Pfam; PF10212; PPP1R21_helical; 1.
DR SMART; SM01254; KLRAQ; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 11..112
FT /note="Protein phosphatase 1 regulatory subunit 21 N-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM01254"
FT REGION 81..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3..72
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 137..196
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 558..592
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 696..737
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 607..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 88562 MW; 29732B5C4796AB58 CRC64;
MASAELQGKY QKLAQEYSKL RAQNQVLKKG VVDEQANSAA LKEQLKMKDQ SLRKLQQEMD
SLTFRNLQLA KRVELLQDEL SLSEPRGKKN KKSGESSSQL SQEQKSVFDE DLQKKIEENE
RLHIQFFEAD EQHKHVEAEL RSRLAALETE AAQHQAVIDG LTRKYMETIE KLQNDKAKLE
VKSQTLEKEA KECRLRTEEC QLQLKNLHED LSGRLEESLS IINEKVPFND TKYSQYNALN
VPLHNRRHQL KMRDIAGQAL TFVQDLVTAL LNFHTYTEQR IQIFPVDSAI DTISPLNQKF
SQYLHENASY VRPLEEGMLH LFESITEDTV TVLETTVKLK TFSEHLTSYI CFLRKILPYQ
LKSLEEECES SLCTSALRAR NLELSQDMRK MTAMFEKLQT YVALLALPST EPDGLLRTNY
SSVLTHVGAA LHGFHDVMKD ISKHYSQKAT IEHELPTATQ KLVTTNDCIL SSVVALTNAA
GKIASFYSNN VDYFITSLSY GPKAASGFIS PLSAECMLQY KKKAAAYMKS LRKPLQESVP
YEEALANRRI LLSSTESREG LAQQVQQSLE KISKLEQEKE HWMLEAQLAK IKLEKENQRI
ADKLKNTSSG QLVGPAQENA AMSNTAGQDE APAKSMPEPV QSTSLIGILT RTSDSEVPDV
ESREDLIKNH YMARIVELTS QLQLADSKSV HFYAECRALS KRLALAEKSK EALTEEMKLA
SQNISRLQDE LTTTKRSYED QLSMMSDHLC SMNETLSKQR EEIDTLKMSS KGNSKKNKSR
//
