ID H0X5S0_OTOGA Unreviewed; 1108 AA.
AC H0X5S0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Pleckstrin homology domain containing A6 {ECO:0000313|Ensembl:ENSOGAP00000010651.2};
GN Name=PLEKHA6 {ECO:0000313|Ensembl:ENSOGAP00000010651.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000010651.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000010651.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03089084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03089085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03089086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03089087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03089088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03089089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03089090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03089091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03089092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03089093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X5S0; -.
DR Ensembl; ENSOGAT00000011910.2; ENSOGAP00000010651.2; ENSOGAG00000011902.2.
DR eggNOG; ENOG502QQHD; Eukaryota.
DR GeneTree; ENSGT00940000159692; -.
DR HOGENOM; CLU_008216_0_0_1; -.
DR InParanoid; H0X5S0; -.
DR OMA; THREMEM; -.
DR TreeFam; TF329090; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR CDD; cd13248; PH_PEPP1_2_3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040392; PKHA4-7_PH.
DR PANTHER; PTHR12752; PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN; 1.
DR PANTHER; PTHR12752:SF5; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 6; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 96..215
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 33..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 609..688
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 35..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..866
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..893
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1092
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 123465 MW; C55F4EFAD085F7E5 CRC64;
SFCLCSHNER RNTFLHPVTG QVPEENKKFD LKTSALDMSN KTGGKRPATT NSDTSNHNMV
SELPPERPNI RATRASRKAV AFGKRSHSMK RNPNAPVTKA GWLFKQASSG VKQWNKRWFV
LLDRCLFYYK DEKEESILGS IPLLSFRVAA VQPSDNISRK HTFKVTVCWV DEAGASSTHC
LSPQAEHAGV RTYFFSAESP EEQEAWIQAM GEAARVQIPP AQKSAPQAVH HGHEKPDSEN
IPPSKHHHQT PHNSLPKPEP EAKTRGEGDG RGCEKAERRP ERPEVKKEPL VKANGILAGP
EPASEPGSPY PEGPRVPGGG EQPAQPNGWQ YSSPSRPGST AFPPQDGESG GHRQSFPPRA
NPDKIAQRKS SMNQLQQWVN LRRGVPPPED LRSPSRFHPV PRRVPEYYGP YSSQYPDDYQ
YYPPGVRPDS ICSMPAYDRI SPPWALEDKR HAFRNGGSPA YQLREWKEST SYGRQDGTVW
IPSPSRQPVY YDELDAASSS LRRLSLQPRS HSVPRSPSQG SYSRARIYSP VRSPSARFER
LPPRSEDIYA DPAAYVMRRS ISSPKVPPYP EVFRDGLHTY KLNEQDTDKL LGKLCEQNKV
VREQERLPVQ SLRAQAESLE SALMGTHQEL EMFGSQPAYP EKLLHKKESL QKQLINIRVE
LSQATTALTN STIEYENLES EVSALHDDLW EQLNLDIQNE VLNRQIQKEI WRIQDVMEGL
RKNNPSRGTD TAKHRGGLGP SATCGSNSPA SPLSSASLTS PLSPFSLVSG SQGSPTKPGS
NEPKANYEQS KKDSHQTSPL DTPRDISLVP TRQEVEAEKQ AALNKVGIVP PRTKSPSDEE
VTPSVVVRRN ANGLSNGLSS QPQERPKSAV FPGEGKVKMS VEEQIDRMRR HQSGSMKEKR
RSLQLPASPA PDPSTRPAYK VVRRHRSIHE VDISNLEAAL RAEEPGGQTY ETPREEIARL
RKMELEPQHY DVDINKELST PDKVLIPERY IDLEPDTPLS PEELKEKQKK VERIKTLIAK
SSMQNVVPIG EGDSVDVPQD SESQLQEQEK RIEISCALAT EASRRGRMLS VQCATPSPPT
SPASPTPPAN PLSSESPRGA DSSHTMRV
//
