ID H0X751_OTOGA Unreviewed; 1222 AA.
AC H0X751;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=ATP-dependent RNA helicase DHX30 {ECO:0000256|ARBA:ARBA00039388};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=DEAH box protein 30 {ECO:0000256|ARBA:ARBA00042917};
GN Name=DHX30 {ECO:0000313|Ensembl:ENSOGAP00000011222.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000011222.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000011222.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC {ECO:0000256|ARBA:ARBA00004436}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; AAQR03163726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03163727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03163728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03163729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03163730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03163731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03163732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03163733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03163734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012667363.1; XM_012811909.1.
DR AlphaFoldDB; H0X751; -.
DR STRING; 30611.ENSOGAP00000011222; -.
DR Ensembl; ENSOGAT00000012533.2; ENSOGAP00000011222.2; ENSOGAG00000012526.2.
DR GeneID; 100941713; -.
DR CTD; 22907; -.
DR eggNOG; KOG0920; Eukaryota.
DR GeneTree; ENSGT00940000158279; -.
DR HOGENOM; CLU_001832_1_2_1; -.
DR InParanoid; H0X751; -.
DR OMA; QYSCTEH; -.
DR OrthoDB; 1095660at2759; -.
DR TreeFam; TF352030; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0042645; C:mitochondrial nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0035770; C:ribonucleoprotein granule; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:1902775; P:mitochondrial large ribosomal subunit assembly; IEA:Ensembl.
DR CDD; cd17976; DEXHc_DHX30; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF229; ATP-DEPENDENT RNA HELICASE DHX30; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion nucleoid {ECO:0000256|ARBA:ARBA00023271};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 472..640
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 682..855
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 17..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..230
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1222 AA; 136174 MW; EA4B44878E8C02E1 CRC64;
MAAARRFMAL AAGVSPRLRP PVPRAAGRQG RSRGISSGCA CPDRTKEAAE AESGMAPGGP
GEGDGSMVNA SRDLLKEFPQ PKNLLNSVIG RALGISHAKD KLVYVHTNGP KKKKVTLHIK
WPKSVEVEGY GSKKIDAERQ AAAAACQLFK GWGLLGPRNE LFDAAKYRVL ADRFGSPADS
WWRPEPTMPP TSWRQLNPES IRPGAPGSLS RSLGREEEDD EEEELEEGTI DVTDFLSMTQ
QDSHTPLRDS RGGSFEMTDD DSAIRALTQF PLPKNLLAKV IQIATSSSTA KNLMQFHTVG
TKTKLSTLTL LWPCPMTFVA KGRRKAEAEN KAAALACKKL KSLGLVDRNN EPLTHAMYNL
ASLRELGETQ RRPCTIQVPE PILRKIETFL NHYPVDSSWT SPELRLQSDD ILPLGKDSGP
LSDPITGKPY MPLSEAEELR LSQSLLELWR RRGPVWQEVP QLPVDPHRDT ILNAIEQHPV
VVISGDTGCG KTTRIPQLLL ERYVTEGRGA RCNVIITQPR RISAVSVAQR VSHELGPSLR
RNVGFQVRLE SKPPARGGAL LFCTVGILLR KLQSNPSLEG VSHVIVDEVH ERDVNTDFLL
ILLKGLQRLN PALRLVLMSA TGDNERFSRY FGGCPVIKVP GFMYPVKEHY LEDILAKLGK
HQYPHRHRHH ESEDECALDL DLVTDLVLHI DAHGEPGGIL CFLPGWQEIK GVQQRLQEAL
GMHESKYLIL PVHSNIPMMD QKAIFQQPPI GVRKIVLATN IAETSITVND IVHVVDSGLH
KEERYDLKTK VSCLETVWVS RANVIQRRGR AGRCQSGFAY HLFPRSRLEK MAPFQVPEIL
RTPLENLVLQ AKIHMPEKTA VEFLSKAVDS PNIKAVDEAV ILLQEIGVLD QREYLTTLGQ
RLAHISTDPR LAKAIVLAAI FRCLHPLLVV VSCLTRDPFS SSLQNRAEVD KVKALLSHDS
GSDHLAFVRA VAGWEEVLRW QDRSSRENYL EENLLYAPSL RFIHGLIKQF SENIYEAFLV
GKPSDCTLAS AQCNEYSEEE ELVKGVLMAG LYPNLIQVRQ GKVTRQGKFK PNSVTYRTKS
GNILLHKSTI NREATRLRSR WLTYFMAVKS NGSVFVRDSS QVHPLAVLLL TDGDVHIRDD
GRRATISLSD SDLLRLEGDS RTVRLLRELR RALSRMVERS LRSELAALPP SVQQEHGQLL
ALLAELLRGP CGSFDVRKTA DD
//
