ID H0X7F1_OTOGA Unreviewed; 777 AA.
AC H0X7F1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Semaphorin 3D {ECO:0000313|Ensembl:ENSOGAP00000011337.2};
GN Name=SEMA3D {ECO:0000313|Ensembl:ENSOGAP00000011337.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000011337.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000011337.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AAQR03012447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03012448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03012449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003782680.1; XM_003782632.2.
DR AlphaFoldDB; H0X7F1; -.
DR STRING; 30611.ENSOGAP00000011337; -.
DR Ensembl; ENSOGAT00000012656.2; ENSOGAP00000011337.2; ENSOGAG00000012652.2.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000156681; -.
DR HOGENOM; CLU_009051_5_0_1; -.
DR InParanoid; H0X7F1; -.
DR OMA; KIYWPAT; -.
DR OrthoDB; 5342713at2759; -.
DR TreeFam; TF316102; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR CDD; cd05871; Ig_Sema3; 1.
DR CDD; cd11252; Sema_3D; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR041416; IL-1RAcP-like_ig.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR042582; Sema3D_Sema.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF36; SEMAPHORIN-3D; 1.
DR Pfam; PF18452; Ig_6; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..531
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 611..680
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 738..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..766
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 89416 MW; 0A668F87004CE34D CRC64;
MNSKKDERPK SRSQDCHLFL ALMMLSMPML FLPVIGTSKQ NIPRLKLTYK DLLLSNSCVP
FLGSSEGLDF QTLLLDEERG KLLLGAKDHI FLLSLVDLNK NFKKIYWPAA KERVELCKLA
GKDINTECAN FIRVLQPYNK THIYACGTGA FHPICGYIDL GVYKEEAVFK LDAHNLESGR
LKCPFDPQQP FASVMTDEYL YSGTASDFLG KDTAFTRSLG PTQDHHYIRT DISEHYWLNG
AKFIGTFPIP DTYNPDDDKI YFFFRESSQE GSTSDKTILS RVGRVCKNDV GGQRSLINKW
TTFLKARLIC SIPGNDGADT YFDELQDIYL LPTRDERNPV VYGVFTTTSS IFKGSAVCVY
SMADIRAVFN GPYAHKESAD HRWVQYDGRI PYPRPGTCPS KTYDPLIKST RDFPDDVISF
IKRHPVMYKS VYPVAGGPTF KRINVDYRLT QIVVDHVIAE DGQYDVMFLG TDIGTILKVV
SISKEKWNME EVVLEELQIF KHPSIILNME LSLKQQQLYI GSRDGLVQLS LHRCDTYGKA
CADCCLARDP YCAWDGNSCS RYAPTSKRRA RRQDVKYGDP ITQCWDIEDS ISHEIADEKV
IFGIEFNSTF LECIPKSQQA SIKWYVQQSG DEHREELKPD ERIIKTEYGL LIRSLQKKDS
GIYYCKAQEH TFIHTIVKLT LNVIENEQME NTQRAEQEEG QVKDLLAESR LRYKDYIQIL
SSPNFSLDQY CEQMWHREKR RQRNKGGPKW KHMQEMKKKR NRRHHADREG FPRAVAT
//
