ID H0X7I1_OTOGA Unreviewed; 587 AA.
AC H0X7I1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Solute carrier family 13 member 3 {ECO:0000313|Ensembl:ENSOGAP00000011368.2};
GN Name=SLC13A3 {ECO:0000313|Ensembl:ENSOGAP00000011368.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000011368.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000011368.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC NADC subfamily. {ECO:0000256|ARBA:ARBA00006772}.
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DR EMBL; AAQR03050232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X7I1; -.
DR STRING; 30611.ENSOGAP00000011368; -.
DR Ensembl; ENSOGAT00000012689.2; ENSOGAP00000011368.2; ENSOGAG00000012685.2.
DR eggNOG; KOG1281; Eukaryota.
DR GeneTree; ENSGT01030000234550; -.
DR HOGENOM; CLU_005170_9_1_1; -.
DR InParanoid; H0X7I1; -.
DR OMA; WISNAAT; -.
DR TreeFam; TF312913; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0015139; F:alpha-ketoglutarate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0034634; F:glutathione transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015362; F:high-affinity sodium:dicarboxylate symporter activity; IEA:Ensembl.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IEA:Ensembl.
DR CDD; cd01115; SLC13_permease; 1.
DR InterPro; IPR001898; SLC13A/DASS.
DR PANTHER; PTHR10283; SOLUTE CARRIER FAMILY 13 MEMBER; 1.
DR PANTHER; PTHR10283:SF62; SOLUTE CARRIER FAMILY 13 MEMBER 3; 1.
DR Pfam; PF00939; Na_sulph_symp; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Sodium {ECO:0000256|ARBA:ARBA00023201};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 23..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 152..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 587 AA; 64428 MW; C4F6085D1E0CADB4 CRC64;
ITWVLGIFIP RPGIVSDSEG RCLYVILLMA VYWCTEALPL SVTALLPIVL FPFMGILPSS
KVCPQYFLDT NFLFLSGLIM ASAIEEWNLH RRIALKVLML IGVQPARLIL GMMVTTSFLS
MWLSNTASTA MMLPIANAIL KSLFGQKEVG KDLSQEREEN TGEAVQRGTG ADATGSGSRM
SGRPRELKFT QVIPGSNHDK GHAEEVEAPL DLLADSKEEE YRRNIWKGFL ISIPYSASIG
GTATLTGTAP NLILLGQLKS FFPQCDVVNF GSWFVFAFPL MLLFLLAGWL WISFLYGGMS
LRSWRAKKSS IRADAEHRAL GVIREEFQSL GPTKFAEQAV FILFCMFAVL LFSRDPKFIP
GWASLFTPGF LSDAVTGVAI VIILFFFPSQ KPSLNLAKQR IISPSAETEP LLTWKKAQET
VPWNIILLLG GGFAMAKGCE ESGLSVWIGG KLHPLENVPP ALAVLLITVV IAFFTEFASN
TATIIIFLPV LAELAIRLRV HPLYLMIPGT VGCSYAFMLP VSTPPNSIAF SSGHLLVKDM
VRTGLLMNLM GVLLLSLAMN TWAQTIFQLG TFPDWANVHS VNVTALP
//
