ID H0X7L7_OTOGA Unreviewed; 681 AA.
AC H0X7L7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Patched domain containing 3 (gene/pseudogene) {ECO:0000313|Ensembl:ENSOGAP00000011411.2};
GN Name=PTCHD3 {ECO:0000313|Ensembl:ENSOGAP00000011411.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000011411.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000011411.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; AAQR03044066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X7L7; -.
DR STRING; 30611.ENSOGAP00000011411; -.
DR Ensembl; ENSOGAT00000012736.2; ENSOGAP00000011411.2; ENSOGAG00000012729.2.
DR eggNOG; KOG1934; Eukaryota.
DR GeneTree; ENSGT00940000158727; -.
DR HOGENOM; CLU_002359_2_2_1; -.
DR InParanoid; H0X7L7; -.
DR OMA; ERMGECM; -.
DR TreeFam; TF331806; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR10796:SF60; PATCHED DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 295..452
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 681 AA; 77763 MW; B8E777CBCC1B4ED4 CRC64;
PAERSVLPLP RLEVPRRRGH WPSSSRWHTD CLEAPLSRAF GRLGWEVGAH PWLFLLLPML
LTAALGTGLY YLPVGKDEDL EEQYTPIGGP AKAERSFVRE HFTTNDSYSF FHSRISSEAN
FASLLVVSDS DTLLEQDILE EVTRLDEQVQ SLSVQVNGSR CGYEDVCAKY KNSCVPPNPL
LYAWQNNKAL NLSAITFPNY DHEGHPLFLT GFFGGNELGK RIGKNHVLQE AKALRLLYFL
KTEVLEDRLK SREWLTHFLN QINTIKKNLN LKKTEVVYFT SLSRQLEFQA TSMTVIPLFH
LAYVLIILFA VISCFRFNCA QNKMWTAIFG VVSAFLAVVS GFGLLLHMGV PFVIIVANSP
FLILGVGVDD MFIMISAWQK TNLTENIRER MSNVFSRVAV SITITTLTNV LAFYTGIMSS
FRSVQYFCIY TGTTLLFCYF YNITCFGAFM ALDGIREEVC LRWLKKSETL DQKYSLFKKF
CFPFGSFVDE DGTEIHPMNL FFRDYFGPFL TTTESKFFVV LIYILYISSS IYGCFQVQEG
LDLRNLASDD SYITPYFNVE EQYFSEYGPR VMVVVTKSIN YWDKHVRQKL ETCMTDFESN
DYVDRDLTEF WLNAYVPYLE GNGQDPNDKN AFINGISGFL TAFPGFTYDI NISPSNEITS
SRGFIQTTHV SSSNNKKIML A
//
