ID H0X885_OTOGA Unreviewed; 308 AA.
AC H0X885;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Platelet-derived growth factor C {ECO:0000256|ARBA:ARBA00018877};
GN Name=PDGFC {ECO:0000313|Ensembl:ENSOGAP00000011671.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000011671.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000011671.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|ARBA:ARBA00006686, ECO:0000256|RuleBase:RU003818}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; AAQR03114593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03114594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03114595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03114596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03114597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03114598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03114599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03114600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03114601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03114602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X885; -.
DR STRING; 30611.ENSOGAP00000011671; -.
DR Ensembl; ENSOGAT00000013031.2; ENSOGAP00000011671.2; ENSOGAG00000013030.2.
DR eggNOG; ENOG502QUUR; Eukaryota.
DR GeneTree; ENSGT00940000158645; -.
DR HOGENOM; CLU_037859_0_0_1; -.
DR InParanoid; H0X885; -.
DR OMA; MCVVIQT; -.
DR TreeFam; TF332130; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005161; F:platelet-derived growth factor receptor binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR11633; PLATELET-DERIVED GROWTH FACTOR; 1.
DR PANTHER; PTHR11633:SF5; PLATELET-DERIVED GROWTH FACTOR C; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU003818}; Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 1..123
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 213..305
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
SQ SEQUENCE 308 AA; 35059 MW; 45CCFE4296BE4D3F CRC64;
VQDPQHERVI TVSSNGSIHS PRFPHTYPRN MVLVWRLVAV EENVWIQLTF DERFGLEDPE
DDLCKYDFVE VEDPNDGAIL GRWCGSGAVP GKQISKGNQI RIRFVSDEYF PSEPGFCIHY
NIVMPQFTEA VSPSVLPPSA LPLDLLNNAV TAFSTLEDLI RYLEPDRWQL DLEDLYRPTW
QLLGKAFVFG RKSRGHVVVD LNLLKEEVRL YSCTPRNFSV SIREELKRTD TIFWPGCLLV
KRCGGNCACC LHNCNECQCV PSKVTKKYHE VLQLRPKNGV RGLHKSLTDI ALEHHEECDC
VCRGNTGG
//
