ID H0X8Z6_OTOGA Unreviewed; 116 AA.
AC H0X8Z6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=SH2 domain-containing protein 1A {ECO:0000256|ARBA:ARBA00013980, ECO:0000256|PIRNR:PIRNR037828};
GN Name=SH2D1A {ECO:0000313|Ensembl:ENSOGAP00000011993.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000011993.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000011993.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cytoplasmic adapter regulating receptors of the signaling
CC lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244,
CC LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with
CC SH2D1B/EAT-2. {ECO:0000256|PIRNR:PIRNR037828}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR037828}.
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DR EMBL; AAQR03175570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03175571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03175572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0X8Z6; -.
DR STRING; 30611.ENSOGAP00000011993; -.
DR Ensembl; ENSOGAT00000013389.2; ENSOGAP00000011993.2; ENSOGAG00000013386.2.
DR eggNOG; KOG0565; Eukaryota.
DR GeneTree; ENSGT00940000155920; -.
DR HOGENOM; CLU_125532_1_0_1; -.
DR InParanoid; H0X8Z6; -.
DR OMA; CVLCNGY; -.
DR TreeFam; TF343096; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0007267; P:cell-cell signaling; IEA:InterPro.
DR GO; GO:0006968; P:cellular defense response; IEA:UniProtKB-UniRule.
DR GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR CDD; cd10400; SH2_SAP1a; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR017289; SH2_prot_1A.
DR InterPro; IPR035876; SH2D1A_SH2.
DR PANTHER; PTHR46051:SF1; IPPC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46051; SH2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00017; SH2; 1.
DR PIRSF; PIRSF037828; SH2_p1A; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130,
KW ECO:0000256|PIRNR:PIRNR037828}; Cytoplasm {ECO:0000256|PIRNR:PIRNR037828};
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037828};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037828};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 6..102
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 116 AA; 12855 MW; 6F5EF0349FEDD264 CRC64;
MDAVTVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYQGY IYTYRVSQTE
TGSWSAETAP GVHKRFFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTG
//
