ID H0XA07_OTOGA Unreviewed; 529 AA.
AC H0XA07;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=DEP domain containing 1B {ECO:0000313|Ensembl:ENSOGAP00000012431.2};
GN Name=DEPDC1B {ECO:0000313|Ensembl:ENSOGAP00000012431.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000012431.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000012431.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03013090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03013091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03013092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03013093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03013094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03013095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03013096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003782788.1; XM_003782740.2.
DR AlphaFoldDB; H0XA07; -.
DR STRING; 30611.ENSOGAP00000012431; -.
DR Ensembl; ENSOGAT00000013884.2; ENSOGAP00000012431.2; ENSOGAG00000013881.2.
DR GeneID; 100953401; -.
DR KEGG; oga:100953401; -.
DR CTD; 55789; -.
DR eggNOG; ENOG502QR00; Eukaryota.
DR GeneTree; ENSGT00950000182976; -.
DR HOGENOM; CLU_040757_0_0_1; -.
DR InParanoid; H0XA07; -.
DR OMA; THVNGKH; -.
DR OrthoDB; 5405142at2759; -.
DR TreeFam; TF328365; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IEA:Ensembl.
DR CDD; cd04447; DEP_BRCC3; 1.
DR CDD; cd04405; RhoGAP_BRCC3-like; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR16206; DEP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR16206:SF11; DEP DOMAIN-CONTAINING PROTEIN 1B; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 24..108
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 201..393
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 529 AA; 61931 MW; E57BA2FCA6848FEB CRC64;
MEHRIVGPGP YRATRLWNET VELFRARMPL RKHRCRFKSY EHCFTAAEAV DWLHELLRCS
QNFGPEVTRK QTVQLLKKFL KNHVIEDIKG KWGQEDFEDN RHLYRFPPSS PLKPYPKKPL
YQKEVIKFPE WNDPPPGTSQ ENIPVKPVVM NSEMWYKRHS IAIGEVPACR LVHRRQLTEA
HVEEIWKSMT LSYLQKILGL DSLEEVLDIK LVNSKFIIHN VYSVSKQGVV ILDDKSKELP
HWVLSAMKCL ANWPNCSDLK QPMYLGFEKD VFKTIADYYG HLKEPLLTFH LFDAFVSVLG
LLQKEKMAVE AFQICCLLLP PENRRKLQLL MRMMARICLN KEMPPLCDGV GTRTLMVQTF
SRCILCSKDE VDLDELLAAR LVTFLMDNYQ EILKVPLALQ TSIEERVAHL RRVQIKYPGA
DMDITLSAPS FCRQISPEEF EYQRAYGSQE PLAALLEEVI TDVKLSSKEK KKKLKQFQKS
YPEVYQERFP TPESEALLFP EKPKPKPQLL MWAFKKPFQP FQRTRSFRM
//
