ID H0XAX5_OTOGA Unreviewed; 1277 AA.
AC H0XAX5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Tenascin N {ECO:0000313|Ensembl:ENSOGAP00000012803.2};
GN Name=TNN {ECO:0000313|Ensembl:ENSOGAP00000012803.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000012803.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000012803.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the tenascin family.
CC {ECO:0000256|ARBA:ARBA00008673}.
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DR EMBL; AAQR03038560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038562; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038566; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03038568; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XAX5; -.
DR STRING; 30611.ENSOGAP00000012803; -.
DR Ensembl; ENSOGAT00000014290.2; ENSOGAP00000012803.2; ENSOGAG00000014283.2.
DR eggNOG; KOG1225; Eukaryota.
DR eggNOG; KOG2579; Eukaryota.
DR GeneTree; ENSGT00940000160553; -.
DR HOGENOM; CLU_001162_0_1_1; -.
DR InParanoid; H0XAX5; -.
DR OMA; EAPIDRY; -.
DR TreeFam; TF329915; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0097442; C:CA3 pyramidal cell dendrite; IEA:Ensembl.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:1990026; C:hippocampal mossy fiber expansion; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0090733; C:tenascin complex; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0033689; P:negative regulation of osteoblast proliferation; IEA:Ensembl.
DR GO; GO:0002076; P:osteoblast development; IEA:Ensembl.
DR GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
DR GO; GO:1903672; P:positive regulation of sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:1903010; P:regulation of bone development; IEA:Ensembl.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:Ensembl.
DR GO; GO:0030334; P:regulation of cell migration; IEA:Ensembl.
DR GO; GO:1905899; P:regulation of smooth muscle tissue development; IEA:Ensembl.
DR CDD; cd00035; ChtBD1; 1.
DR CDD; cd00063; FN3; 7.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 6.10.250.2590; -; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR020837; Fibrinogen_CS.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR PANTHER; PTHR46708:SF5; TENASCIN N; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR Pfam; PF00041; fn3; 7.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00186; FBG; 1.
DR SMART; SM00060; FN3; 7.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50853; FN3; 7.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT DOMAIN 334..422
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 512..605
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 606..691
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 692..782
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 783..865
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 870..959
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 960..1048
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1044..1261
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT REGION 444..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 72..99
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1277 AA; 140420 MW; C0F6560C43FCC4BB CRC64;
SNKEQQVTVS HTYKIDVPKS ALVQVEADPQ HLRDNGASLL ALEEAGEEQN IVFRHNIRLQ
TPQKDCELAG SVQDFLARVK KLEEEMAEMR EQCSAQRCCQ GAAGELTTYL SRHCSGHGTF
SLVTCSCHCE QGWEGAACEQ PACPGACSGH GRCEDGRCLC DEPFVGADCA YPACPENCSG
HGVCVRGVCR CHENFTSEDC SERRCPGDCS GHGFCDTGEC YCEEGFTGLD CAQGESREAP
SSRLSLHPGT VNSHCPIWRS PSRDLKAMCA SVYLSISYQI ISSGGSCMVP DTGLHPPPAI
IVLSRGQVRS ECSVGGPTLL PPSLPHPLLP TVVAPQGLQL LKSTEDSLLV SWEPSSEVDH
YLLSYYPLGK ELSGKQIQVP KEQNSYEILG LLPGTRYIVT LRNVKKDVSS SPQHLLATTG
EGPARCSGFS EEASCIQSLP EKDGASALRA RQGHSGPRGF KATGRTGTSH PEVISEGRVP
AAKGHWGVTD LQDFHSSLLS LASLNPSLDL SVLGTAWVTD ETENSLDVEW ENPPTEVDYY
KLRYGPMTGQ EVAEVTVPKS SDPKSRYDIT GLQPGTEYNI TVVPVRGELE GRPILLNGRT
EIDGPTNVVT DRVTEDTATV SWDPVQAVID KYMVRYTSAD GETKETAVHR DQSSTTLTGL
RPGDAYKVYV WAERGSQGSK KADTKALTDI DSPQNLVTDR VTENTATVSW DPVQAAIDRY
VVRYTSADDG ETKEVPVGKE QSSTVLTGLR PGVEYTVHVW AEKGTQESKK AGTKTPTDID
SPQNLITDWV TENTATVSWD PVQAAIDRYV VRYTSADDGE TKEVPVGKEQ SSTVLTGLRP
GVEYMVYVWA EKGTRESKKA DTKAPTDIDS PQNLVTNRVT ENTVTVSWDP VQAAIDRYMV
RYTSADGDTK EVPVGKEQSS TVLKGLRPGV EYTVYVWAEK GTRESKKADT RAWTEIDPPR
NLRPSAVTQS GGVLTWTPPS AQIDGYILTY QFPDGTIKEV QLGWDFQRFE LQDLEQGITY
PVSLVAFKGD RQSRSASTTL STVGARFPHP LDCSQVQQNS NAASGLYTIY LHGDASRPLQ
VYCDMDTDGG GWIVFQRRNT GQLDFFKRWR SYVEGFGDPM KEFWLGLDKL HNLTMGTATR
YEVRVDLQTA NESAYAIYDF FQVASSKERY KLTVGKYRGT AGDALSYHNG WKFTTFDRDN
DIALSNCALT HHGGWWYKNC HLANPNGRYG ETKHSEGVNW EPWKGHEFSI PYVELKIRPH
GYSSDRVLGR KKRTLGG
//
