ID H0XAZ3_OTOGA Unreviewed; 468 AA.
AC H0XAZ3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=F-box protein 3 {ECO:0000313|Ensembl:ENSOGAP00000012830.2};
GN Name=FBXO3 {ECO:0000313|Ensembl:ENSOGAP00000012830.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000012830.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000012830.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; AAQR03002494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03002495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03002496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003781267.1; XM_003781219.2.
DR AlphaFoldDB; H0XAZ3; -.
DR STRING; 30611.ENSOGAP00000012830; -.
DR Ensembl; ENSOGAT00000014322.2; ENSOGAP00000012830.2; ENSOGAG00000014318.2.
DR GeneID; 100967126; -.
DR KEGG; oga:100967126; -.
DR CTD; 26273; -.
DR eggNOG; KOG4408; Eukaryota.
DR GeneTree; ENSGT00940000153571; -.
DR HOGENOM; CLU_056869_0_0_1; -.
DR InParanoid; H0XAZ3; -.
DR OMA; YVHDKDC; -.
DR OrthoDB; 5362121at2759; -.
DR TreeFam; TF329795; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IEA:Ensembl.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR CDD; cd22084; F-box_FBXO3; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.60.40.1470; ApaG domain; 1.
DR Gene3D; 3.40.1580.10; SMI1/KNR4-like; 1.
DR InterPro; IPR007474; ApaG_domain.
DR InterPro; IPR036767; ApaG_sf.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR018958; Knr4/Smi1-like_dom.
DR InterPro; IPR037883; Knr4/Smi1-like_sf.
DR PANTHER; PTHR46550; F-BOX ONLY PROTEIN 3; 1.
DR PANTHER; PTHR46550:SF6; F-BOX ONLY PROTEIN 3; 1.
DR Pfam; PF04379; DUF525; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF09346; SMI1_KNR4; 1.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00860; SMI1_KNR4; 1.
DR SUPFAM; SSF110069; ApaG-like; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF160631; SMI1/KNR4-like; 1.
DR PROSITE; PS51087; APAG; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 10..56
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT DOMAIN 278..408
FT /note="ApaG"
FT /evidence="ECO:0000259|PROSITE:PS51087"
FT REGION 419..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..445
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 468 AA; 54072 MW; C60E9582B8EDD684 CRC64;
MAAMEAEATP LTLGSLPTDP LLLILSFLDY RDLINCCYVS RRLSQLSSHD PLWRRHCKKY
WLISEEEKTQ QDQCWKSLFI DTYSDVGRYI NHYAAIKKAW DNLKKYLEPR CPRMVLSLKE
GAREEDLDAV EAQIGCKLPD DYRCSYRIHN GQKLVVPGLL GSMALSNHYR SEDLLDVDTA
AGGFQQRQGL KYCLPLTFCI HTGLSQYIAV EAAEGRNKNE VFYQCPDQMA RNPAAIDMFI
TGATFTDWFT SYVNNVVSGG FPIIRDQIFR YIHDPECVAT TGDITVSVST SFLPELSSVH
PPHYFFTYRI RIEMSKDALP EKACQLDSRY WRITNAKGDV EEVQGPGVVG EFPIISPGRV
YEYTSCTTFS TTSGYMEGYY TFHFLYFKDK IFNVAIPRFH MACPTFRVSI ARLEMGPDEY
EEMEEEEEEE EEDDDSADMD ESDEDDEEER RRRVFDVPIR RRRCSRLF
//