ID H0XB09_OTOGA Unreviewed; 1017 AA.
AC H0XB09;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Formin like 2 {ECO:0000313|Ensembl:ENSOGAP00000012846.2};
GN Name=FMNL2 {ECO:0000313|Ensembl:ENSOGAP00000012846.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000012846.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000012846.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family.
CC {ECO:0000256|ARBA:ARBA00023449}.
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DR EMBL; AAQR03123617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03123618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03123619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03123620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03123621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XB09; -.
DR STRING; 30611.ENSOGAP00000012846; -.
DR Ensembl; ENSOGAT00000014338.2; ENSOGAP00000012846.2; ENSOGAG00000014332.2.
DR eggNOG; KOG1923; Eukaryota.
DR GeneTree; ENSGT00940000155515; -.
DR HOGENOM; CLU_003597_0_0_1; -.
DR InParanoid; H0XB09; -.
DR OMA; MMPGFSP; -.
DR TreeFam; TF325155; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:Ensembl.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR043592; FMNL_animal.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR45857:SF5; FORMIN-LIKE PROTEIN 2; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00022707};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 1..403
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 547..938
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 970..1007
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 449..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 315..412
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 912..943
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 449..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..530
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1017 AA; 115363 MW; 882E660C69055004 CRC64;
QERFQVKNPP HTYIQKLKGY LDPAVTRKKF RRRVQESTQV LRELEISLRT NHIGWVREFL
NEENKGLDVL VEYLSFAQYA VTFDFESVES TVESSVEKSK PWSRSIEDLH RGSNLPSPVG
SGAARSGRHS ALRYNTLPRR RTLKNSRLVS KKDDIHVCIM CLRAIMNYQY GFNMVMSHPH
AVNEIALSLN NKNPRTKALV LELLAAVCLV RGGHEIILSA FDNFKEVCGE KQRFEKLMEH
FRNEDNNIDF MVASMQFINI VVHSVEDMNF RVHLQYEFTK LGLDEYLDKL KHTESDKLQV
QIQAYLDNVF DVGALLEDAE TKNAALERVE ELEENISHLS EKLQDTENEA MSKIVELEKQ
LMQRNKELDV VREIYKDANT QVHTLRKMVK EKEEAIQRQS TLEKKIHELE KQGTIKIQKK
GDGDIAILPV VASGTLSMGL EVGVGNSGGP VTGATSSGSL AHPPLPPSSD SPETVQNGPV
TPPMPPPPPP PPPPPPPPPP PPPLPGPAAE TAPAPPVPPP PPPSAPPLPG TSSPTVVFNS
GLAAVKIKKP IKTKFRMPVF NWVALKPNQI NGTVFNEIDD ERILEDLNVD EFEEIFKTKA
QGPAIDLSSS KQKITQKGSS KVTLLEANRA KNLAITLRKA GKTADEICKA IHVFDLKTLP
VDFVECLMRF LPTENEVKVL RLYERERKPL ENLSDEDRFM MQFSKIERLM QKMTIMAFIG
NFAESIQMLT PQLHAIIAAS VSIKSSQKLK KILEIILALG NYMNSSKRGA VYGFKLQSLD
LLLDTKSTDR KQTLLHYISN VVKEKYHQVS LFYNELHYVE KAAAVSLENV LLDVKELQRG
MDLTKREYTM HDHNTLLKEF ILNNEGKLKK LQDDAKIAQD AFDDVVKYFG ENPKTTPPSV
FFPVFVRFVK AYKQAEEENE LRKKQEQALM EKLLEQEALM EQQDPKSPSH KSKRQQQELI
AELRRRQVKD NRHVYEGKDG AIEDIITVLK TVPFTARTAK RGSRFFCEPV LTEEYHY
//
