ID H0XBL8_OTOGA Unreviewed; 491 AA.
AC H0XBL8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Poly(A)-specific ribonuclease PARN {ECO:0000256|ARBA:ARBA00015918};
DE EC=3.1.13.4 {ECO:0000256|ARBA:ARBA00012161};
DE AltName: Full=Polyadenylate-specific ribonuclease {ECO:0000256|ARBA:ARBA00031923};
GN Name=PARN {ECO:0000313|Ensembl:ENSOGAP00000013110.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000013110.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000013110.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001663};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CAF1 family.
CC {ECO:0000256|ARBA:ARBA00008372}.
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DR EMBL; AAQR03180736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03180737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03180738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03180739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03180740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03180741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03180742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03180743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03180744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03180745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XBL8; -.
DR STRING; 30611.ENSOGAP00000013110; -.
DR Ensembl; ENSOGAT00000014636.2; ENSOGAP00000013110.2; ENSOGAG00000014626.2.
DR eggNOG; KOG1990; Eukaryota.
DR GeneTree; ENSGT00940000153167; -.
DR HOGENOM; CLU_018030_1_1_1; -.
DR InParanoid; H0XBL8; -.
DR OMA; LTTCHED; -.
DR TreeFam; TF314502; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0000495; P:box H/ACA RNA 3'-end processing; IEA:Ensembl.
DR GO; GO:0010587; P:miRNA catabolic process; IEA:Ensembl.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR GO; GO:0110008; P:ncRNA deadenylation; IEA:Ensembl.
DR GO; GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IEA:Ensembl.
DR GO; GO:0032212; P:positive regulation of telomere maintenance via telomerase; IEA:Ensembl.
DR GO; GO:1904872; P:regulation of telomerase RNA localization to Cajal body; IEA:Ensembl.
DR GO; GO:0090669; P:telomerase RNA stabilization; IEA:Ensembl.
DR CDD; cd02637; R3H_PARN; 1.
DR CDD; cd12428; RRM_PARN; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR034042; PARN_R3H.
DR InterPro; IPR014789; PolyA-riboNase_RNA-binding.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR15092; POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1; 1.
DR PANTHER; PTHR15092:SF44; POLY(A)-SPECIFIC RIBONUCLEASE PARN; 1.
DR Pfam; PF04857; CAF1; 1.
DR Pfam; PF08675; RNA_bind; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS51061; R3H; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 176..243
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
SQ SEQUENCE 491 AA; 56761 MW; ABDB02D0F55A2A8C CRC64;
MEIIRSNFKS NLHKVYQAIE EADFFAIDGE FSGISDGPSV SALTNGFDTP EERYQKLKKA
NHSMDFLLFQ FGLCTFKYDY TDSKYITKSF NFYVFPKPFN RFSPDVKFVC QSSSIDFLAS
QGFDFNKVFH NGIPYLNQEE ERQLREQYDE KRSQANGAYV SPNASKCRLT IPEDQKKFID
QVVEKIEDLL QSEENKNLDL EPCTGFQRKL IYQTLSWKYP KGIHVETLET EKKEQYIAIS
KVDEEERKRR EQEKHAKEQE ELNDAVGFSR VIHAIANSGK LVIGHNMLLD VMHTVHQFYY
PLPADLTDFK KMTTCVFPRL LDTKLMASTQ PFKDIINNTS LAELEKRLKE TPFCSPKVES
AEGFPSYDTA SEQLHEAGYD AYITGLCFIS MANYLGSFLS PPEIHVSARS KLIEPFFNKL
FLMRLMDIPY LNLEGPDLQP KRDHVLHVTF PKEWKASNLY RLFSAFGNIQ ISWIDDTSAF
VSLSQPEQVQ I
//
