ID H0XBY9_OTOGA Unreviewed; 2874 AA.
AC H0XBY9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=WNK1 {ECO:0000313|Ensembl:ENSOGAP00000013258.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000013258.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000013258.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; AAQR03128397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03128398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03128399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03128400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03128401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03128402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03128403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03128404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03128405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03128406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000013258; -.
DR Ensembl; ENSOGAT00000014804.2; ENSOGAP00000013258.2; ENSOGAG00000014795.2.
DR eggNOG; KOG0584; Eukaryota.
DR GeneTree; ENSGT00940000155474; -.
DR HOGENOM; CLU_000550_0_1_1; -.
DR InParanoid; H0XBY9; -.
DR OMA; PEPNGMT; -.
DR TreeFam; TF315363; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140693; F:molecular condensate scaffold activity; IEA:Ensembl.
DR GO; GO:0019902; F:phosphatase binding; IEA:Ensembl.
DR GO; GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006884; P:cell volume homeostasis; IEA:Ensembl.
DR GO; GO:0071474; P:cellular hyperosmotic response; IEA:Ensembl.
DR GO; GO:0038116; P:chemokine (C-C motif) ligand 21 signaling pathway; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0030644; P:intracellular chloride ion homeostasis; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR GO; GO:0097022; P:lymphocyte migration into lymph node; IEA:Ensembl.
DR GO; GO:0010507; P:negative regulation of autophagy; IEA:Ensembl.
DR GO; GO:0033633; P:negative regulation of cell-cell adhesion mediated by integrin; IEA:Ensembl.
DR GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR GO; GO:1903038; P:negative regulation of leukocyte cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0090188; P:negative regulation of pancreatic juice secretion; IEA:Ensembl.
DR GO; GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:0140694; P:non-membrane-bounded organelle assembly; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:1903490; P:positive regulation of mitotic cytokinesis; IEA:Ensembl.
DR GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; IEA:Ensembl.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IEA:Ensembl.
DR GO; GO:1904595; P:positive regulation of termination of RNA polymerase II transcription; IEA:Ensembl.
DR GO; GO:0055075; P:potassium ion homeostasis; IEA:Ensembl.
DR GO; GO:0045050; P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence; IEA:Ensembl.
DR GO; GO:0010793; P:regulation of mRNA export from nucleus; IEA:Ensembl.
DR GO; GO:1902305; P:regulation of sodium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
DR CDD; cd14030; STKc_WNK1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024678; Kinase_OSR1/WNK_CCT.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR13902; SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED; 1.
DR PANTHER; PTHR13902:SF46; SERINE_THREONINE-PROTEIN KINASE WNK1; 1.
DR Pfam; PF12202; OSR1_C; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 222..480
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1205..1282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1528..1617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2226..2252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2359..2434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2604..2688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2701..2738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1528..1547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1555..1589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1593..1613
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2226..2240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2361..2377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2378..2398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2625..2688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2702..2736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2874 AA; 304200 MW; 073E738F47A53967 CRC64;
MSGGAAEKQS STPSSLFLSP PAPAPKNGSS SDSSVGEKLG AAASDAGGGR TEEYRRRRHT
MDKDSRGAAA TTTTTEHRFF RRSVICDSNA TALEVPGLPL SLPQSSVPAV VPQSAPPEPH
REEPLTVTAA SQVAQQPPAA AAPGDQAVAG LAASATPSST SKDRPVSQPN LVGSKEETPP
ARSGSGGGGS AKEPQEERSQ QQDDIEELET KAVGMSNDGR FLKFDIEIGR GSFKTVYKGL
DTETTVEVAW CELQDRKLSK SERQRFKEEA EMLKGLQHPN IVRFYDSWES TVKGKKCIVL
VTELMTSGTL KTYLKRFKVM KIKVLRSWCR QILKGLQFLH TRTPPIIHRD LKCDNIFITG
PTGSVKIGDL GLATLKRASF AKSVIGTPEF MAPEMYEEKY DESVDVYAFG MCMLEMATSE
YPYSECQNAA QIYRRVTSGV KPASFDKVAI PEVKEIIEGC IRQNKDERYS IKDLLNHAFF
QEETGVRVEL AEEDDGEKIA IKLWLRIEDI KKLKGKYKDN EAIEFSFDLE RDVPEDVAQE
MVESGYVCEG DHKTMAKAIK DRVSLIKRKR EQRQLVREEQ EKRKQEESSL KQQVEQQFSA
SQTGVKQLPS ASTGVPTAST TSASVSTQVE PEEPEADQHQ QLQYPQPTLS VLSDGTVDSG
QGSSVFTESR VSSQQTVSYG SQHEQAHSTG TIPGHTASVV QAQSQPHGVY PPSSLPRRGR
SMSVCPIFLL FPLCPALHPV FYPTTSVVCI SFSFPPSDCP ESFAEKLSKA LESVLPMHSA
SQRKHRRSSL PSLFVSTPQS MAHPCGGTPT YPESQIFFPT IHERPVSFSP PPTCPPKVAI
SQRRKSTSFL EAQTHHFQPL LRTVGQNHLP PGGSPTNWTP EAVVMLGTTA SRITTEPCEI
QVHPMFETTQ VYSDCKPGLI LPEEAHYFIP QEAVYLAGVH YQAQVAEQYE GIPYNSQVLS
SPMKQIPEQK PVQGVPTSSS VFEFPSGQAF LVGHVQNLRL DSGLSPGSPL SSISAPISTD
ATRLKFHPVF VPHSAPAVLT HSNESRSSCV FEFHVHTPSS SSGEGGGILP QRAYRNRQVA
VDLNLEELPP QSSGLHGHLQ PVTEEQHNYH APELTVSVVE PFGQNWPIGS PEYSSDSSQI
TSSDPSDFQS PPPTGGAAAP LGSDVSLPFI RLPQTVFQES PLFFCFPQGT TSQQVLTASF
SSGGSALQSQ AQGQSQGQLS SSSLTGISSS QSLQHPQQQG IQQTAPPQQT VQYSLPQTST
SGEATTAQPV SQPQAPQVLS QVSAGKQLPV SQPVPPIQGE PQIPVATQPS VVPVHSGAHF
LPMGQPLPTS LLPQYPISQI PISTSHVSTA QTGFSSIPIT MAAGINQPLL TLASSATAAA
IPGVTTVVPS QLPTLLQPVT QMPSQVHPQL LQPAVQSMGI PANLGQAAEV PLPSGDVLYQ
GFPPRLPPQY PGDSNIAPSS SVASVCIHST VLSPPMPTEA LATPAYFPAV VQPYVESNLL
VPVGGIGGQV QVSQPAVSLA QQAPTTSSQQ AALESTQGVS QVVSPEPIPV TQPQPTQPTN
LVSSIDSAHS DVASGMSDGN ENVPSSSGRH EGRTTKRHYR KSVRSRSRHE KTSRPKLRIL
NVSNKGDRVV ECQLETHNRK MVTFKFDLDG DNPEEIATIM VNNDFILAIE RESFVDQVRE
IIEKADEMLS EDVSVEPEGD QGLESLQGKD DYGFSGSQKL EGEFKQPIPA SSMPQQIGIP
TSSLTQVVHS AGRRFIVSPV PESRLRESNL FTSEISDTVA ASTSQGPGMN LSHSASSLSL
QQAFSELKHA QTTEGPNTAP PNFTHTGPVF PVVPPSLSST AGVSTIAAAT SSVSIPITSS
PSNDMSVIQS EIIVPTEKAI AGVAISTGMA TSGGLPIPPV SESPLISNVV SSITVPPIAS
VTTTSQSVQA PASGSVISST GTFPSITVSI ASASKVGSIA VPCAKPPAVP SQQAAGSTTP
VATLTSVSAT TSLSNTASQT SLQLSSSTSA PTLAETVVVS AHSLDKTSHS STAGLALSLS
APSSCSSQGA GVSSSASQPA GVHPLVIPSA VVSTPVLSQA AGPTPLLPQV PSIPPLIQPV
ANVPAVQQTL IHSQPQPALL PNQPHTHCPE IDADTQPKAP GIDDIKTLEE KLRSLFSEHS
SSGAQHASVS LETSLVVETT VTPGIPTTAV APSKLMTSTT STCLPPTNLP LGTVALPGIP
VVTPGQAPTP VSTTSGVKSG MAPSKPPLAK APVLPVGTEL PTGTLSSEQL PPFPGPSLTQ
SQQPLEDLDA QLRRTLSPET ITVTTAVGPV SMVAPIAVTE SGAQPQKDVS QGTEGHVLAT
TSGAGVFKMG RFQVSVAMDD AQKEGKNKPE DAKSVHFESS TSESSVLSSS SPESTVVKPA
PNGITIHSIS SDVPDSAHKT PAPEAKSETG QPTKVGRFQV SSTANKVGRF SVSRTEDKIA
EAKKEGTLTS PPYVDLEQAI LPAVIPKKEK PELSEPSHLN GPSSDLEAAF LSRDVDDGSG
SPRSPHQLCS KSLPIQTLSQ SLSNSFNSSY MSSDNESDIE DEDLKLELRR LREKHLKEIQ
DLQSRQKHEI ESLYTKLGKV PPAVIIPPAA PLSGRRRRPT KSKGSKSSRS SSLGNKSPQL
SGNLSGQSAA SVLHPQQTLH PPGNIPESGQ NQLLQPLKPS PSSDNLYSAF TSDGAISVPS
LAAPGQGTSS TNTVGGTVNS QAAQAQPPAM TSSRKGTFTD DLHKLVDNWA RDAMNLSGRR
GSKGHMNYEG PGMARKFSAP GQLCISMTSN LGGSAPISAA SATSLGHFTK SLCPPQQYGF
PAAPFGAQWS GTGGPAPQPL GQFQPVGTAS LQNFNISNLQ KSISNPPGSN LRTT
//
