ID H0XC09_OTOGA Unreviewed; 600 AA.
AC H0XC09;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Proline dehydrogenase {ECO:0000256|RuleBase:RU364054};
DE EC=1.5.5.2 {ECO:0000256|RuleBase:RU364054};
GN Name=LOC100963160 {ECO:0000313|Ensembl:ENSOGAP00000013278.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000013278.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000013278.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate.
CC {ECO:0000256|RuleBase:RU364054}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a
CC quinol + H(+); Xref=Rhea:RHEA:23784, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17388, ChEBI:CHEBI:24646, ChEBI:CHEBI:60039,
CC ChEBI:CHEBI:132124; EC=1.5.5.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000978,
CC ECO:0000256|RuleBase:RU364054};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|RuleBase:RU364054};
CC -!- PATHWAY: Amino-acid degradation; L-proline degradation into L-
CC glutamate; L-glutamate from L-proline: step 1/2.
CC {ECO:0000256|ARBA:ARBA00004739}.
CC -!- SIMILARITY: Belongs to the proline oxidase family.
CC {ECO:0000256|ARBA:ARBA00005869, ECO:0000256|RuleBase:RU364054}.
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DR EMBL; AAQR03174542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003801765.1; XM_003801717.2.
DR AlphaFoldDB; H0XC09; -.
DR STRING; 30611.ENSOGAP00000013278; -.
DR Ensembl; ENSOGAT00000014825.2; ENSOGAP00000013278.2; ENSOGAG00000014819.2.
DR GeneID; 100963160; -.
DR KEGG; oga:100963160; -.
DR eggNOG; KOG0186; Eukaryota.
DR GeneTree; ENSGT00390000006265; -.
DR HOGENOM; CLU_018202_3_1_1; -.
DR InParanoid; H0XC09; -.
DR OMA; GPLKKYH; -.
DR OrthoDB; 5473051at2759; -.
DR TreeFam; TF313544; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0004657; F:proline dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0006562; P:proline catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.220; -; 2.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR002872; Proline_DH_dom.
DR InterPro; IPR015659; Proline_oxidase.
DR PANTHER; PTHR13914:SF0; PROLINE DEHYDROGENASE 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13914; PROLINE OXIDASE; 1.
DR Pfam; PF01619; Pro_dh; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|RuleBase:RU364054};
KW Flavoprotein {ECO:0000256|RuleBase:RU364054};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU364054};
KW Proline metabolism {ECO:0000256|ARBA:ARBA00023062,
KW ECO:0000256|RuleBase:RU364054};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 270..571
FT /note="Proline dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF01619"
SQ SEQUENCE 600 AA; 67947 MW; 12F57FDB9409D466 CRC64;
MALKHVWSFL CPGLPRLAPL STAPAAREQS AAGPRAVSAC GVAETVRPPV PSVDFGNAQE
AYRSRRSWEL VRSLLVLRLC ASTTLLARHE QLLHITRKLL GQRLFDKLMK MTFYGQFVAG
EDQESIRPLI QHNRAFGVGS ILDYGVEEDL STEEAQCKEM ESCTSAAERD GSGTSKRKKQ
YQAHWAFGDR RDGVISARTY FYANEAKCDS HLETFLRCIE ASGCACEDGF SAIKLTALGR
PQFLLQFSDV LTKWRRFFHQ MAAEQGQAGL AAKDMKLEVA ALQESIAKMG IAPRAEIQDW
FTVETLGVSG TVDLLDWSSL IDSRTKLSQH LVVPNTQTGQ LEPLLSQFTE EEELQMTRML
QRIDVLAKKA REMGVRLMVD AEQTYFQPAI SHLTLEMQRK FNVDRPLIFN TYQCYLKDAY
DNVTLDMELA HREGWCFGAK LVRGAYMAQE RARAAEIGYE DPINSTYEAT NTMYHRCLDY
VLQELKHNAK AQVMVASHNE DTIRFTLCRM EELGLHPVDR QVYFGQLLGM CDQISFPLGQ
AGFPVYKYVP YGPVMEVLPY LSRRALENSS LMKGAQRERQ LLWKELKRRL LTGSLFHCPA
//