ID H0XC15_OTOGA Unreviewed; 643 AA.
AC H0XC15;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN Name=KIF12 {ECO:0000313|Ensembl:ENSOGAP00000013286.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000013286.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000013286.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
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DR EMBL; AAQR03034700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03034701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XC15; -.
DR STRING; 30611.ENSOGAP00000013286; -.
DR Ensembl; ENSOGAT00000014835.2; ENSOGAP00000013286.2; ENSOGAG00000014830.2.
DR eggNOG; KOG4280; Eukaryota.
DR GeneTree; ENSGT00940000161216; -.
DR HOGENOM; CLU_001485_2_1_1; -.
DR InParanoid; H0XC15; -.
DR OMA; YISHQTA; -.
DR TreeFam; TF324584; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00106; KISc; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47969; CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED; 1.
DR PANTHER; PTHR47969:SF15; ZGC:66125; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 24..359
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 381..462
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 103..110
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 643 AA; 70488 MW; 84E69EF69B3EE2FA CRC64;
EERGSPDGDP ARSLEQGPEG PETPIQVVLR VRPMSTAELR RGEQSVLHCS GTRTLQGGPE
VAFRFGAVLD GARTQEDVFR ACGVRRLGEL ALRGFSCTVF TFGQTGSGKT YTLTGPPPQG
EGVPVPPSLA GIMQRTFTWL LDRVQHLPAP VTLRASYLEI YNDQVRDLLS LGSPRPLPVR
WNKTRGFYVE QLRVVEFSSL EALMELLQMG LSRRRSSAHT LNQASSRSHA LLTVYISCRT
AQQMPPVGPG EPPVGGKLCF VDLAGSEKVT ATGSRGELML EANSINRSLL ALGHCISLLL
DPQRKQSHIP FRDSKLTKLL ADSLGGRGVT LMVACVSPSA QCLPETLSTL RYASRAQRVT
TRPQAPKSPV AKLPQRVETD MLQLQEENRH LQFQLDQMER KASGLSGTQM AWAQQNLYGM
LQEFMLENER LRKEKRQLQS SRDQAQSEQR ILAQQVQELQ RRLSACYHHQ PSPGPAPPCP
CLMVPPPSCH ALPPLSSCPW RHLCPICQAP LAHWACPWRE RHVQQVLGPE APGGRPLSAR
PPPWAPTCSS SSAKCPRERS HSDWTQTRVL AEMLTEEEVV PSAPPLPTGP PSTSPVLRGG
AGVQNLAQRL EALRDQIGSS LRRGRSQPPH SEGARSPGPG LSP
//
