ID H0XC47_OTOGA Unreviewed; 1240 AA.
AC H0XC47;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Jumonji and AT-rich interaction domain containing 2 {ECO:0000313|Ensembl:ENSOGAP00000013325.2};
GN Name=JARID2 {ECO:0000313|Ensembl:ENSOGAP00000013325.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000013325.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000013325.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03055816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03055817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03055818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03055819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03055820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03055821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03055822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03055823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03055824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03055825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003788365.1; XM_003788317.1.
DR AlphaFoldDB; H0XC47; -.
DR STRING; 30611.ENSOGAP00000013325; -.
DR Ensembl; ENSOGAT00000014881.2; ENSOGAP00000013325.2; ENSOGAG00000014876.2.
DR GeneID; 100963185; -.
DR KEGG; oga:100963185; -.
DR CTD; 3720; -.
DR eggNOG; KOG1246; Eukaryota.
DR GeneTree; ENSGT00940000159220; -.
DR HOGENOM; CLU_007086_0_0_1; -.
DR InParanoid; H0XC47; -.
DR OMA; TGADCIX; -.
DR OrthoDB; 48111at2759; -.
DR TreeFam; TF323264; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0035098; C:ESC/E(Z) complex; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0046976; F:histone H3K27 methyltransferase activity; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IEA:Ensembl.
DR GO; GO:0061649; F:ubiquitin modification-dependent histone binding; IEA:Ensembl.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0140718; P:facultative heterochromatin formation; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1902682; P:protein localization to pericentric heterochromatin; IEA:Ensembl.
DR GO; GO:0060816; P:random inactivation of X chromosome; IEA:Ensembl.
DR GO; GO:0048536; P:spleen development; IEA:Ensembl.
DR GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR CDD; cd16870; ARID_JARD2; 1.
DR Gene3D; 1.10.150.60; ARID DNA-binding domain; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR InterPro; IPR004198; Znf_C5HC2.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR10694:SF113; PROTEIN JUMONJI; 1.
DR Pfam; PF01388; ARID; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR Pfam; PF02928; zf-C5HC2; 1.
DR SMART; SM01014; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SUPFAM; SSF46774; ARID-like; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51011; ARID; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 551..592
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 615..707
FT /note="ARID"
FT /evidence="ECO:0000259|PROSITE:PS51011"
FT DOMAIN 878..1042
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1202..1240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..194
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..496
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..538
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1225..1240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1240 AA; 137950 MW; 203BFBBA9741DF94 CRC64;
MSKERPKRNI IQKKYDDSDG IPWSEERVVR KVLYLSLKEF KNSQKRQHGE GIAGSLKTVN
GLLGNDQSKG LGPASEQSEN EKDDASQVSS ASNDVSSSDF EEGPSRKRPR LQAQRKFAQS
QPNSPSTTPV KIAEPLLPPP VTQISDLSKR KPKTEDFLTF LCLRGSPALP NSMVYFGSSQ
DEEDVEEEDE ETEDVKTATN NASSSCQSTP RKGKTHKHAH NGHVFNGSSR STREKEPVQK
HKSKEATPGK EKHSDHRADS RREQASANQP TAAPSTATPA KGPAASHHHP PLPRSAQDLR
KQVSKVNGVT RMSSLGAGAA SAKKMREVRP SPSKTVKYTA TVTKGAVTYT KAKRELVKET
KPTHHKPSSA VNHTISGKTE SSNAKTRKQV LSLGGASKST GPAVNGLKVS GRLNPKSCTK
EVGGRQLREG LRNSKRRLEE AHQAEKPQSP PKKMKGAAGP ADSPGKKAPA EKALLNGHLK
KEVPERSLER NRPKRATAGK STPGRQAHGK ADGASCENRS TSQPESLHKP HDSAKAEKGG
GKTGWAAMDE IPVLRPSAKE FHDPLIYIES VRAQVEKFGM CRVIPPPDWR PECKLNDEMR
FVTQIQHIHK LGRRWGPNVQ RLACIKKHLR SQGITMDELP LIGGCELDLA CFFRLINEMG
GMQQVTDLKK WNKLADMLRI PKTAQDRLAK LQEAYCQYLL SYDSLSPEEH RRLEKEVLME
KEILEKRKGP LEGHTENDHH KFHPLPRFEP KNGLIHGVAP RNGFRSKLKE VGQAQLKTGR
RRLFAQEKEV VKEEEEDKGV LNDFHKCIYK GRSVSLTTFY RTARNIMNMC FSKEPAPAEI
EQEYWRLVEE KDCHVAVHCG KVDTNTHGSG FPVGKSEPFS RHGWNLTVLP NNTGSILRHL
GAVPGVTIPW LNIGMVFSTS CWSRDQNHLP YIDYLHTGAD CIWYCIPAEE ENKLEDVVHT
LLQANGTPGL QMLESNVMIS PEVLCKEGIK VHRTVQQSGQ FVVCFPGSFV SKVCCGYSVS
ETVHFATTQW TSMGFETAKE MKRRHIAKPF SMEKLLYQIA QAEAKKENGP TLSTISSLLD
ELRDTELRQR RQLFEAGLHS SARYGSHDGS STAADGKKKP RKWLQLETSE RRCQICQHLC
YLSMVVQENE NVVFCLECAL RHVEKQKSCR GLKLMYRYDE EQIISLVNQI CGKVSGKNGS
IENCLSKPTP KRGPRKRATV DVPPSRLSAS GSSRSASSSS
//
