ID H0XCQ8_OTOGA Unreviewed; 461 AA.
AC H0XCQ8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Serine incorporator 5 {ECO:0000256|ARBA:ARBA00021252};
GN Name=SERINC5 {ECO:0000313|Ensembl:ENSOGAP00000013592.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000013592.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000013592.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TDE1 family.
CC {ECO:0000256|ARBA:ARBA00006665}.
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DR EMBL; AAQR03040214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XCQ8; -.
DR STRING; 30611.ENSOGAP00000013592; -.
DR Ensembl; ENSOGAT00000015183.2; ENSOGAP00000013592.2; ENSOGAG00000015178.2.
DR eggNOG; KOG2592; Eukaryota.
DR GeneTree; ENSGT01030000234623; -.
DR HOGENOM; CLU_029574_5_2_1; -.
DR InParanoid; H0XCQ8; -.
DR OMA; LCCVMMS; -.
DR OrthoDB; 53161at2759; -.
DR TreeFam; TF312881; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR005016; TDE1/TMS.
DR PANTHER; PTHR10383; SERINE INCORPORATOR; 1.
DR PANTHER; PTHR10383:SF16; SERINE INCORPORATOR 5; 1.
DR Pfam; PF03348; Serinc; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 461 AA; 51150 MW; D9E4690F6E67019D CRC64;
MSARCCAGQL ACCCGTAGCS LCCDCCPKIR QSRSTRCMYA LYFILVVGLC CIMMSKTVAK
EMREHIPFFE DMCKGIKAGD SCENLVGYSA VYRVCFGMAC FFFIFCLLTL KISNSKSCRA
QIHNGFWFFK LLLLAALCSG AFFIPDQETF LNAWLYVGAV GGFLFIGIQL FLLVEFAHKW
NKNWTAGTAS NKLWYASLAL ATLIMYSIAA AGLISMAIFY TQKVGCLENK ILLGINGGLC
LLISIVAISP SVLERQPHSG LLQSGLISCY VTYLTFSALT SKPVDLVLDE HGKNVTICVP
NFGQDLYRDE NLVTGLGTFL LLGCILYSCL TSTTRSSSDA LQGRCADPEL EVARCCFCFG
PDGEDTDDEQ QAKDGPRVIY DEKKGTVYNY SYFHFMFFLA SLYVMVTITS WFNYESAHLE
AFFSGNRSIF WVKMASCWIC VLLYLGTLLI PLCRPAPHYS V
//
