ID H0XDF8_OTOGA Unreviewed; 1408 AA.
AC H0XDF8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRU {ECO:0000313|Ensembl:ENSOGAP00000013902.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000013902.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000013902.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR EMBL; AAQR03165972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03165973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03165974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03165975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03165976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000013902; -.
DR Ensembl; ENSOGAT00000015529.2; ENSOGAP00000013902.2; ENSOGAG00000015523.2.
DR eggNOG; KOG4228; Eukaryota.
DR GeneTree; ENSGT00940000157151; -.
DR HOGENOM; CLU_001645_0_2_1; -.
DR InParanoid; H0XDF8; -.
DR OMA; WEQVRSH; -.
DR TreeFam; TF312900; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0034109; P:homotypic cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:2000049; P:positive regulation of cell-cell adhesion mediated by cadherin; IEA:Ensembl.
DR GO; GO:0034394; P:protein localization to cell surface; IEA:Ensembl.
DR CDD; cd00063; FN3; 3.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14632; R-PTPc-U-1; 1.
DR CDD; cd14637; R-PTPc-U-2; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF10; PROTEIN-TYROSINE-PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 720..745
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..163
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 263..358
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 361..459
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 460..566
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 882..1109
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1029..1100
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1141..1404
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1320..1395
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 798..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..812
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1408 AA; 158282 MW; 5526BB31E53CBEEB CRC64;
GCTFEETSDP AVPCEYSQAQ YDDFQWEQVR IHPGTRAPAD LPHGSYLMVN TSQHAPGQRA
HVIFQSLSEN DTHCVQFSYF LYSRDGHSPG TLGVYVRVNG GPLGSAVWNM TGSHGRQWHQ
AELAVSTFWP NEYQVLFEAL ISPDRRGYMG LDDILLLSYP CAKAPHFSRL GDVEVNAGQN
ASFQCMAAGR AAEAERFLLQ RQSGALVPAV SVRHISHRRF LATFPLVAVG RPEQDLYRCV
SQAPRGAGVS NFAELIVKEP PTPIAPPQLL RAGPTYLIIQ LNTNSIIGDG PIVRKEIEYR
MSRGPWAEVH AVSLQTYKLW HLDPDTEYEI SVLLTRPGDG GTGRPGPPLI SRTKCAEPMR
APKGLAFAEI QARQLTLQWE PLGYNVTRCH TYTVSLCYHY TPGSSHNQTI RECVKTEPGA
SRYTIKNLLP YRNVHVRLVL TNPEGRKEGK EVTFQTDEDV PGGIAAESLT FTPLEDMIFL
KWEEPQEPNG LITQYEISYQ SIESSDPAVN VPGPRRTISK LRNETYHVFS NLHPGTTYLF
SVRARTSKGF GQAALTEITT NISAPSFDYA DMPSPLGESE DTITVLLRPA QGRGAPISVY
QVIVEEERPR RLRREPGGQD CFPVPLTFEA ALARGLVHYF GAELAASSLP EAMPFTVGDN
QTYRGFWNPP LEPRKAYLIY FQATSHLKGE TRLNCIRIAR KAACKESKRP LEVSQRSEEM
GLILGICAGG LAVLILLLGA IIVIIRKGKP VNMTKATVNY RQEKTHMMSA VDRSFTDQST
LQEDERLGLS FMDTHGYSSR GDQRSGAVTE ASSLLGGSPR RPCGRKGSPY HTGQLHPAVR
VADLLQHINQ MKTAEGYGFK QEYESFFEGW DATKKKDKLK GSRQEPMPAY DRHRVKLHPM
LGDPNADYIN ANYIDGYHRS NHFIATQGPK PEMVYDFWRM VWQEHCSSIV MITKLVEVGR
VKCSRYWPED SDMYGDIKIT LVKTETLAEY VVRTFALERR GYSARHEVRQ FHFTAWPEHG
VPYHATGLLA FIRRVKASTP PDAGPIVIHC SAGTGRTGCY IVLDVMLDMA ECEGVVDIYN
CVKTLCSRRV NMIQTEEQYI FIHDAILEAC LCGETTIPVS EFRATYKEMI RIDPQSNSSQ
LREEFQTLNS VTPPLDVEEC SIALLPRNRD KNRSMDVLPP DRCLPFLIST DGDPNNYINA
ALTDSYTRSA AFIVTLHPLQ STTPDFWRLV YDYGCTSIVM LNQLNQSNSA WPCLQYWPEP
GRQQYGLMEV EFVSGTADED LVARVFRVQN ISRLQEGHLL VRHFQFLRWS AYRDTPDSKK
AFLHLLTEVD KWQAENGDGR TVVHCLNGGG RSGTFCACAT VLEMIRCHSL VDVFFAAKTL
RNYKPNMVET MDQYHFCYDV ALEYLEGL
//
