ID   H0XDP1_OTOGA            Unreviewed;       414 AA.
AC   H0XDP1;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   Name=NEU3 {ECO:0000313|Ensembl:ENSOGAP00000013995.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000013995.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000013995.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-
CC         (2->8)- glycosidic linkages of terminal sialic acid residues in
CC         oligosaccharides, glycoproteins, glycolipids, colominic acid and
CC         synthetic substrates.; EC=3.2.1.18;
CC         Evidence={ECO:0000256|ARBA:ARBA00000427};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; AAQR03001084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0XDP1; -.
DR   STRING; 30611.ENSOGAP00000013995; -.
DR   Ensembl; ENSOGAT00000015628.2; ENSOGAP00000013995.2; ENSOGAG00000015623.2.
DR   eggNOG; ENOG502QSFT; Eukaryota.
DR   GeneTree; ENSGT00950000182944; -.
DR   HOGENOM; CLU_024620_2_0_1; -.
DR   InParanoid; H0XDP1; -.
DR   OMA; ECGIKRE; -.
DR   TreeFam; TF331063; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0031901; C:early endosome membrane; IEA:Ensembl.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0055038; C:recycling endosome membrane; IEA:Ensembl.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006689; P:ganglioside catabolic process; IEA:Ensembl.
DR   GO; GO:1900186; P:negative regulation of clathrin-dependent endocytosis; IEA:Ensembl.
DR   GO; GO:0009313; P:oligosaccharide catabolic process; IEA:Ensembl.
DR   GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF23; SIALIDASE-3; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT   DOMAIN          50..378
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   414 AA;  46661 MW;  CF64E3D5054C37E1 CRC64;
     IEEVTSCTIN SCLFQQEDEK GITYRIPALL YVPPFHTFLA FAEKRSTVRD EDALYLVLRR
     GVRIGRSVQW EPLKLLMEAT LPGHRTMNPC PVWEKNSGYV FLFFICVRGH VTEYEQIVSG
     RNAARLCFIC SQDAGRSWSE VRDLTEEVIG PEVKHWATFA VGPGHGIQMQ SGRLVIPAYT
     YYIPYWFSCL RIPCRVRPHS LMIFSDDLGA TWHHGSLIRP LVTVECEVAE VTGRTGHSVL
     YCSARTPNRC RAEALSIDSG ECFQRAALSQ QLREPPHGCQ GSVVSFLPLQ ILHRCQNPSG
     QDAPTIQQTL PDSSLRLEEE AGIPSQSWLL YSHPVNSKRR VDLGIYLNQA PLEVACWSHP
     WILHHGPCGY SDLAAVEEDG LFACLFECGT KQGCEQIAFR LFTNREVLTH IQGD
//