ID H0XDS9_OTOGA Unreviewed; 1158 AA.
AC H0XDS9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN Name=MAN2A1 {ECO:0000313|Ensembl:ENSOGAP00000014042.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000014042.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000014042.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR EMBL; AAQR03059625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03059626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XDS9; -.
DR STRING; 30611.ENSOGAP00000014042; -.
DR Ensembl; ENSOGAT00000015677.2; ENSOGAP00000014042.2; ENSOGAG00000015667.2.
DR eggNOG; KOG1958; Eukaryota.
DR GeneTree; ENSGT01030000234638; -.
DR HOGENOM; CLU_004690_1_0_1; -.
DR InParanoid; H0XDS9; -.
DR OMA; WRQNWDM; -.
DR TreeFam; TF313152; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005801; C:cis-Golgi network; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005797; C:Golgi medial cisterna; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0016799; F:hydrolase activity, hydrolyzing N-glycosyl compounds; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR GO; GO:0007005; P:mitochondrion organization; IEA:Ensembl.
DR GO; GO:0006491; P:N-glycan processing; IEA:Ensembl.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl.
DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:Ensembl.
DR GO; GO:0060042; P:retina morphogenesis in camera-type eye; IEA:Ensembl.
DR GO; GO:0007033; P:vacuole organization; IEA:Ensembl.
DR CDD; cd11666; GH38N_Man2A1; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF70; ALPHA-MANNOSIDASE 2; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 501..589
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1158 AA; 132773 MW; 46A9FFBBB6CEA088 CRC64;
MKLSRQFTVF GSAIFCVVIF SLYLMLDRGH LDYPKNPRRE GSFPQGQLSM LQEKIDHLER
LLAENNEIIS NIRDSVINLS ESVEDGPKSS QGNFSQGAGA HLLSQLSLSV DPADCQFASQ
SGSPNSDVQM LDVYSLLSFD NPDGGVWKQG FDIEYETKEW DTEPLQVFVV PHSHNDPGWL
KTFNDYFRDK TQYIFNNMVV KLAEDSRRKF IWSEISYLSK WWDIIDNQKK DAVKSLIENG
QFEIVTGGWV MPDEATSHYF ALIDQLIEGH QWLENNLGVK PRSGWAIDPF GYSPTMAYLL
KLSGFSHMLI QRVHYAIKKH FSLQKSLEFY WRQNWDLGSV TDILCHMMPF YSYDIPHTCG
PDPKICCQFD FKRLPGGRVG CPWGVPPETI HAGNIHSRAS LLLDQYRKKS KLFRSKVLLA
PLGDDFRYCE YTEWDLQFKN YQRLFDYMNS QSKFNVKIQF GTLSDYFDAL DKADANQREK
RQSMFPVVSG DFFTYADRDD HYWSGYFTSR PFYKRMDRII ESHLRIRAAE ILYYFALRQA
EKYKINTFLS SPYYKTLTEA RRNLGLFQHH DAITGTAKDW VVVDYGTRLF HSLMALEEII
GHSAFLLILK DKQSYEVYDS YSSDTLDMDF KQKSQDSLPQ KNIIQLSTKP RYLVVFNPLE
QDRVSVVSVY VSSPTVQVLS ASGQPMQVQV SAVWDAANVI SKTAYEVSFL ARVPPLGMKV
FRILKSATSN SHLADYVFYN GKIEDTVSKN KVEDTGIFKI KNKQNAEEAI TLENSFIALW
FAPSGLLEKM MAKEDGKLHE VKVQFSWYGT TSKIDKSGAY LFLPDGEAKP YVYNELPLVI
VTRGRIYSEV TCSFEHVIHR VRLYHVQGIE GQSVEISNIV DIRKVYNREI AMRISSDIKS
QNRFYTDLNG YQIQPRVTMR KLPLQANVYP MTTMAYIQDA EHRLTLLSAQ SLGVSSLSSG
EIEVIMDRRL MQDDNRGLGQ GCHDNKITAN LFRILLERRS AVNMEEEKRP VSFPSLLSHI
TSSFMNHPVF PMTKKFSPTL KLLGEFSPLL SSLPCDIHLV NLRTLQSKVG GGYSNEAALI
LHRKGFDCRF SSKDTGLLCP TTQGKMLVQK LFNKFTIESL TLSSLSLMHS SPDAQNISEI
NLSPMEISTF RVRLSFWL
//
