ID H0XE09_OTOGA Unreviewed; 775 AA.
AC H0XE09;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=SPG7 matrix AAA peptidase subunit, paraplegin {ECO:0000313|Ensembl:ENSOGAP00000014144.2};
GN Name=SPG7 {ECO:0000313|Ensembl:ENSOGAP00000014144.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000014144.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000014144.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000256|ARBA:ARBA00010550}.
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DR EMBL; AAQR03166411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03166412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03166413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03166414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03166415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03166416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03166417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03166418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03166419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03166420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XE09; -.
DR STRING; 30611.ENSOGAP00000014144; -.
DR Ensembl; ENSOGAT00000015797.2; ENSOGAP00000014144.2; ENSOGAG00000015790.2.
DR eggNOG; KOG0731; Eukaryota.
DR GeneTree; ENSGT00940000156329; -.
DR HOGENOM; CLU_000688_23_2_1; -.
DR InParanoid; H0XE09; -.
DR OMA; TRMKSMK; -.
DR TreeFam; TF105003; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0005745; C:m-AAA complex; IEA:Ensembl.
DR GO; GO:0005757; C:mitochondrial permeability transition pore complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0008089; P:anterograde axonal transport; IEA:Ensembl.
DR GO; GO:1902686; P:mitochondrial outer membrane permeabilization involved in programmed cell death; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd19501; RecA-like_FtsH; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.1690.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011546; Pept_M41_FtsH_extracell.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR NCBIfam; TIGR01241; FtsH_fam; 1.
DR PANTHER; PTHR43655; ATP-DEPENDENT PROTEASE; 1.
DR PANTHER; PTHR43655:SF8; PARAPLEGIN; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF06480; FtsH_ext; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 128..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 324..464
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 734..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 195..222
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 745..759
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 775 AA; 86081 MW; F7CD207C62FD463E CRC64;
LAGPLLVMRT LRQGPWPGPA RLWGSGCGGR PSLYTGAGRR WPYWVIRPPV GRPLQSLQFR
LLTPTFEEIS GLLLKQHLVP NRVRLWQLLG IVMKPDSAST KKKKAIEAKE RRRREREDQM
YRERLRTLFV IAVVMSLLNS LSTSGGNISW SDFVNEMLAK GEVQRVQVVP ESDVVEVYLH
PGAVVFGRPR LALMYRMQVA NIDKFEEKLR AAEDELNIDG KDRILVSYKR AGFFGNALYA
VGMTAVGLAI LWYVFRLAGM AGREGGFSAF NQLKMARFTI VDGKMGKGVS FKDVAGMHEA
KLEVREFVDY LKSPERFLQL GAKVPKGALL LGPPGCGKTL LAKAVATEAQ VPFLAMAGPE
FVEVIGGLGA ARVRSLFKEA RARAPCIVYI DEIDAVGKKR STTTAGFSNT EEEQTLNQLL
VEMDGMGTTD HVIVLASTNR ADILDNALMR PGRLDRHVFI DLPTLQERRE IFEQHLKSLK
LTQASTFYSQ RLAELTPGFS GADIANICNE AALHAAREGH TSVHTFNFEY AVERVLAGTA
KKSKILSQEE QKVVAFHESG HALVGWLLEH TEAVMKVSIA PRTNAALGFA QMLPRDQHLF
TREQLFERMC MALGGRASEA IAFSRVTSGA QDDLRKVTRI AYSMVKQFGM APGIGPIAFP
EAQEGFAVVG RRPFSQGLQQ MMDHEAKLLV ARAYRHTEKV LLDNWDKLQA LASALLEKEV
INYEDIEALI GPPPHGPKKM IAPQRWIDAQ REKQDPGEEA EAPLPPQGEE PSWPK
//
