ID H0XE75_OTOGA Unreviewed; 684 AA.
AC H0XE75;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Zinc finger protein 263 {ECO:0008006|Google:ProtNLM};
GN Name=ZNF263 {ECO:0000313|Ensembl:ENSOGAP00000014230.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000014230.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000014230.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00187}.
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DR EMBL; AAQR03078226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03078227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012661314.1; XM_012805860.1.
DR AlphaFoldDB; H0XE75; -.
DR STRING; 30611.ENSOGAP00000014230; -.
DR Ensembl; ENSOGAT00000015890.2; ENSOGAP00000014230.2; ENSOGAG00000015888.2.
DR GeneID; 105886330; -.
DR KEGG; oga:105886330; -.
DR CTD; 10127; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000159965; -.
DR HOGENOM; CLU_002678_49_8_1; -.
DR InParanoid; H0XE75; -.
DR OMA; QQVTNQG; -.
DR OrthoDB; 4624489at2759; -.
DR TreeFam; TF350829; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 9.
DR Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23226:SF394; FI01424P-RELATED; 1.
DR PANTHER; PTHR23226; ZINC FINGER AND SCAN DOMAIN-CONTAINING; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00187}; Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 41..123
FT /note="SCAN box"
FT /evidence="ECO:0000259|PROSITE:PS50804"
FT DOMAIN 217..289
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 379..406
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 435..462
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 463..490
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 491..518
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 519..546
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 576..603
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 604..631
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 632..659
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 660..684
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 230..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 78239 MW; D7F579016E12DC8E CRC64;
MASGQSSQEQ EGLLIVKLEE DCVWSQELPP SDPGPSPEAS HLRFRRFRFQ EAAGPREALS
RLQELCHGWL RPEMHTKEQI LELLVLEQFL IILPQEIQSR VQELHPESGE EAVTLVEDMQ
RELGRLRQQV TNHGRGTEVV LEEPLPLETA QESPSFKLEP VETERSLGPR LQELLGPSPK
REPQAAKERA LSAPWLSLFP PEGNIEDKEM TGPQLPESIE DVAVYISQEE WGHQDPSKRA
LSRDTVQESY ENVDSLESHI PRQEIPTTQV EQERKPWDAN VQSCKEGLSL RSPAQGKEKF
ENLEENSQSV SPENTHPQSL LPLQAGGEVP WSPDQGRPHD RAEGNWEPPP EGHLEQPLIG
ATNYRELGRP RELQPKKLHL CPLCGKNFSN NSNLIRHQKI HATERLYMGV ECGEIFGGNP
HFLSLHRAHL GEEAHKCLEC GKCFSQNTHL TRHQRTHTGE KPYQCNICGK SFSCNSNLHR
HQRTHTGEKP YKCPECGEIF AHSSNLLRHQ RIHTGERPYK CPECGKSFSR SSHLVIHERT
HEKERLYSFS ECGEAMNDSA PFFTNHRVHK TEKKVFECLT CGKSFRQGMH LTRHQRTHTG
EKPYKCTLCG ENFSHRSNLI RHQRIHTGEK PYTCHECGDS FSHSSNRIRH LRTHTGERPY
KCSECGESFS RSSRLMSHQR THTG
//
